CASTOR1

cytosolic arginine sensor for mTORC1 subunit 1

Summary

Enables several functions, including arginine binding activity; identical protein binding activity; and protein sequestering activity. Involved in cellular response to L-arginine; cellular response to amino acid starvation; and regulation of TORC1 signaling. Located in GATOR2 complex and cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Known Variants19 total

rsidPosition (GRCh37)AllelesClassClinVar
rs104309922:30,681,257C/A
rs55577848622:30,681,634C/Tuncertain significance
rs20176734222:30,681,647C/Guncertain significance
rs57421307922:30,681,653C/Tuncertain significance
rs126300610122:30,681,659C/Tuncertain significance
rs122296993722:30,681,671C/Tuncertain significance
rs130156871522:30,682,017G/Auncertain significance
rs129641546222:30,682,031C/Tuncertain significance
rs192978577222:30,682,851C/Tuncertain significance
rs37713230522:30,682,857C/Tuncertain significance
rs20146485522:30,682,865G/Auncertain significance
rs76199795722:30,682,907C/Tuncertain significance
rs104007075522:30,683,146T/Cuncertain significance
rs75042590122:30,683,189C/Auncertain significance
rs74965913022:30,683,242G/Auncertain significance
rs77390542622:30,683,255C/Tuncertain significance
rs77920781422:30,683,466G/Tuncertain significance
rs20024340322:30,685,384G/Auncertain significance
rs5597957522:30,687,066C/T

Gene information from NCBI Gene. Variant classifications from ClinVar.