rs1043099
This variant is located in the CASTOR1 gene.
▶Research that mentions this SNP (1)
▶Novel Rheumatoid Arthritis Susceptibility Locus at 22q12 Identified in an Extended UK Genome‐Wide Association StudyAssociationN=8,305Gisela Orozco et al.(2014)· Arthritis & Rheumatology
This extended UK genome-wide association study identified a novel rheumatoid arthritis susceptibility locus at 22q12 (rs1043099, P = 6.9 × 10⁻⁹, OR = 0.84) in 3,034 cases and 5,271 controls, and confirmed 16 previously known RA loci, strengthening evidence for genetic contributors to RA in the UK population.
About CASTOR1
Enables several functions, including arginine binding activity; identical protein binding activity; and protein sequestering activity. Involved in cellular response to L-arginine; cellular response to amino acid starvation; and regulation of TORC1 signaling. Located in GATOR2 complex and cytosol. [provided by Alliance of Genome Resources, Jul 2025]
View all CASTOR1 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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