CCND3
cyclin D3
Summary
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activtiy is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
Known Variants55 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs759741362 | 6:41,903,733 | C/T | — | uncertain significance |
| rs33966734 | 6:41,903,798 | C/A | missense variant | — |
| rs763029528 | 6:41,903,812 | C/T | — | uncertain significance |
| rs1353553597 | 6:41,904,319 | G/A | — | uncertain significance |
| rs11552780 | 6:41,904,324 | C/G | — | benign |
| rs374294883 | 6:41,905,026 | C/T | — | uncertain significance |
| rs750688882 | 6:41,905,087 | C/A | — | uncertain significance |
| rs2479717 | 6:41,905,174 | T/G | — | — |
| rs3218097 | 6:41,905,275 | G/T | — | — |
| rs1410492 | 6:41,907,855 | G/C | regulatory region variant | — |
| rs762395134 | 6:41,908,131 | C/T | — | uncertain significance |
| rs147998619 | 6:41,908,157 | T/C | — | uncertain significance |
| rs755858491 | 6:41,908,269 | G/T | — | uncertain significance |
| rs11552782 | 6:41,908,273 | G/A | — | benign |
| rs772291509 | 6:41,908,278 | T/C | — | uncertain significance |
| rs778979671 | 6:41,909,291 | G/C | — | uncertain significance |
| rs1430025445 | 6:41,909,336 | C/T | — | uncertain significance |
| rs3218085 | 6:41,910,179 | G/T | regulatory region variant | — |
| rs9349204 | 6:41,914,378 | A/T | — | — |
| rs147929970 | 6:41,915,514 | G/A | intron variant | — |
| rs12528656 | 6:41,916,072 | T/G | intron variant | — |
| rs186985563 | 6:41,917,526 | C/T | intron variant | — |
| rs188976494 | 6:41,918,964 | A/C | intron variant | — |
| rs9296369 | 6:41,920,996 | C/T | — | — |
| rs11758590 | 6:41,920,997 | C/A | — | — |
| rs16895128 | 6:41,924,369 | G/C | — | — |
| rs9349205 | 6:41,925,159 | G/A | regulatory region variant | benign |
| rs11970772 | 6:41,925,290 | T/A | regulatory region variant | — |
| rs11968166 | 6:41,925,304 | G/A | regulatory region variant | — |
| rs193035899 | 6:41,930,305 | C/G | intron variant | — |
| rs72853818 | 6:41,934,104 | G/C | intron variant | — |
| rs72853828 | 6:41,941,993 | T/C | intron variant | — |
| rs9367118 | 6:41,942,568 | T/C | intron variant | — |
| rs7774393 | 6:41,946,440 | C/G | intron variant | — |
| rs577951214 | 6:41,947,249 | G/A | — | — |
| rs36102271 | 6:41,953,861 | T/A | intron variant | — |
| rs9471708 | 6:41,956,353 | C/G | intron variant | — |
| rs9471709 | 6:41,956,585 | T/C | intron variant | — |
| rs9357377 | 6:41,962,671 | G/A | intron variant | — |
| rs116565956 | 6:41,968,668 | T/A | intron variant | — |
| rs10948001 | 6:41,970,950 | C/T | — | — |
| rs58707300 | 6:41,974,507 | G/A | intron variant | — |
| rs72664259 | 6:41,986,269 | A/G | upstream gene variant | — |
| rs142449754 | 6:41,986,427 | C/T | upstream gene variant | — |
| rs1483765759 | 6:41,986,447 | T/C | — | — |
| rs56144648 | 6:41,988,742 | G/A | upstream gene variant | — |
| rs144703702 | 6:41,989,930 | A/G | upstream gene variant | — |
| rs185836749 | 6:41,990,629 | C/T | regulatory region variant | — |
| rs72664260 | 6:41,990,791 | C/G | — | — |
| rs7750688 | 6:41,991,740 | C/G | — | — |
| rs4711702 | 6:41,992,518 | C/A | — | — |
| rs12199246 | 6:41,999,809 | G/A | downstream gene variant | — |
| rs116307341 | 6:42,001,195 | A/T | downstream gene variant | — |
| rs12201437 | 6:42,015,886 | C/T | upstream gene variant | — |
| rs10456506 | 6:42,016,246 | T/C | regulatory region variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.