CCR6
C-C motif chemokine receptor 6
Summary
This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The gene is preferentially expressed by immature dendritic cells and memory T cells. The ligand of this receptor is macrophage inflammatory protein 3 alpha (MIP-3 alpha). This receptor has been shown to be important for B-lineage maturation and antigen-driven B-cell differentiation, and it may regulate the migration and recruitment of dentritic and T cells during inflammatory and immunological responses. Alternatively spliced transcript variants that encode the same protein have been described for this gene. [provided by RefSeq, Jul 2008]
Known Variants24 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs1012657 | 6:167,525,142 | A/T | — | — |
| rs968334 | 6:167,526,096 | T/C | regulatory region variant | — |
| rs112853039 | 6:167,526,466 | G/A | — | — |
| rs1999460 | 6:167,532,755 | A/G | regulatory region variant | — |
| rs3093024 | 6:167,532,793 | A/G | regulatory region variant | — |
| rs1854853 | 6:167,533,062 | A/G | upstream gene variant | — |
| rs3093023 | 6:167,534,290 | G/C | — | — |
| rs59466457 | 6:167,537,754 | A/G | — | — |
| rs10946216 | 6:167,538,897 | T/C | intron variant | — |
| rs1571878 | 6:167,540,842 | C/T | intron variant | — |
| rs62436827 | 6:167,548,547 | A/G | coding sequence variant | — |
| rs766231476 | 6:167,549,629 | G/A | — | uncertain significance |
| rs2483510892 | 6:167,549,852 | C/T | — | uncertain significance |
| rs1224171378 | 6:167,549,867 | C/T | — | uncertain significance |
| rs145186145 | 6:167,549,868 | G/A | — | likely benign |
| rs1781852222 | 6:167,549,998 | C/T | — | uncertain significance |
| rs201556077 | 6:167,550,047 | C/T | — | uncertain significance |
| rs566661955 | 6:167,550,188 | G/A | — | uncertain significance |
| rs41510645 | 6:167,550,195 | A/G | — | benign |
| rs747278885 | 6:167,550,205 | C/A | — | uncertain significance |
| rs2483512551 | 6:167,550,565 | A/G | — | uncertain significance |
| rs1583003329 | 6:167,550,754 | T/C | — | uncertain significance |
| rs17860852 | 6:167,550,824 | C/T | — | likely benign |
| rs1781865646 | 6:167,550,838 | A/G | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.