CDC14A

cell division cycle 14A

Summary

The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. It is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, suggesting a role in cell cycle control. This protein has been shown to interact with, and dephosphorylate tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splicing of this gene results in several transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

Known Variants190 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs199528581	1:100,817,340	A/G	—	likely benign
rs529737374	1:100,817,753	G/A	—	likely benign
rs549887762	1:100,817,754	C/G	—	likely benign
rs542747022	1:100,818,041	A/G	—	likely benign
rs529224	1:100,818,178	G/C	—	benign
rs527644	1:100,818,286	T/A	—	benign
rs594529	1:100,818,464	T/C	—	likely benign
rs571098288	1:100,818,538	G/C	—	conflicting classifications of pathogenicity
rs140623300	1:100,818,541	G/A	—	conflicting classifications of pathogenicity
rs377636796	1:100,818,545	G/A	—	uncertain significance
rs757539865	1:100,818,569	A/T	—	likely benign
rs502955	1:100,818,694	A/G	—	likely benign
rs17420882	1:100,818,728	G/T	—	benign
rs2297170	1:100,819,273	T/C	—	benign
rs762772245	1:100,819,307	T/G	—	likely benign
rs2100872719	1:100,819,317	G/T	—	likely pathogenic
rs2100872783	1:100,819,328	T/C	—	likely benign
rs796559022	1:100,819,366	A/G	—	uncertain significance
rs149981742	1:100,819,689	C/G	—	likely benign
rs114558965	1:100,829,685	A/C	regulatory region variant	—
rs28361201	1:100,842,809	T/C	—	likely benign
rs28361203	1:100,842,873	G/T	—	benign
rs201731089	1:100,843,153	C/T	—	likely benign
rs757576834	1:100,843,164	A/G	—	uncertain significance
rs2100948826	1:100,843,175	A/G	—	uncertain significance
rs766342104	1:100,845,504	G/A	—	—
rs10875289	1:100,847,969	G/T	—	—
rs17122369	1:100,856,025	T/A	—	benign
rs375521987	1:100,856,268	T/A	—	likely benign
rs2524017035	1:100,856,281	T/C	—	likely benign
rs376488789	1:100,856,314	A/G	—	uncertain significance
rs143209870	1:100,856,322	A/G	—	uncertain significance
rs2524017246	1:100,856,325	C/G	—	uncertain significance
rs140021980	1:100,856,373	C/G	—	conflicting classifications of pathogenicity
rs28361212	1:100,856,380	A/C	—	benign
rs28361213	1:100,856,479	C/T	—	benign
rs188427266	1:100,856,525	A/G	—	benign
rs28361214	1:100,856,647	A/T	—	benign
rs56953413	1:100,870,418	C/A	intron variant	—
rs612683	1:100,880,328	A/T	—	benign
rs17122450	1:100,889,760	A/G	—	benign
rs1295586658	1:100,889,808	G/A	—	uncertain significance
rs2524176431	1:100,889,817	G/A	—	uncertain significance
rs184524418	1:100,889,825	G/C	—	likely benign
rs144409876	1:100,889,838	C/G	—	uncertain significance
rs200941208	1:100,889,842	C/G	—	uncertain significance
rs6662924	1:100,894,419	C/T	—	—
rs28361228	1:100,905,346	G/A	—	likely benign
rs28361229	1:100,905,405	C/T	—	likely benign
rs1664742874	1:100,905,492	G/T	—	uncertain significance
rs771622183	1:100,905,515	C/G	—	pathogenic
rs774957073	1:100,905,554	G/A	—	uncertain significance
rs28361230	1:100,905,569	C/T	—	likely benign
rs76679045	1:100,905,665	A/G	—	likely benign
rs601077	1:100,905,762	G/A	—	likely benign
rs584350	1:100,908,324	A/G	—	benign
rs202211124	1:100,908,484	T/C	—	likely benign
rs138318034	1:100,908,504	A/C	—	benign
rs568592855	1:100,908,509	T/A	—	uncertain significance
rs760703579	1:100,908,521	C/A	—	uncertain significance
rs780275633	1:100,908,545	A/T	—	uncertain significance
rs78861171	1:100,908,577	A/T	—	benign
rs10493926	1:100,908,634	T/C	—	benign
rs78315260	1:100,908,678	T/G	—	benign
rs6687508	1:100,908,726	A/G	—	benign
rs11166454	1:100,910,367	G/T	—	—
rs28364871	1:100,920,901	T/C	—	likely benign
rs28364872	1:100,920,945	T/C	—	likely benign
rs765155697	1:100,920,961	C/T	—	likely pathogenic
rs2524299347	1:100,920,964	G/A	—	uncertain significance
rs750581079	1:100,920,983	A/G	—	uncertain significance
rs2524299734	1:100,921,022	C/G	—	likely pathogenic
rs755291422	1:100,921,027	C/T	—	uncertain significance
rs28364873	1:100,921,078	C/A	—	likely benign
rs17122554	1:100,921,190	A/G	—	benign
rs114112363	1:100,921,230	A/T	—	likely benign
rs7526455	1:100,923,262	T/G	—	—
rs481443	1:100,924,684	G/A	—	—
rs28364883	1:100,928,055	G/T	—	benign
rs114626664	1:100,928,197	G/A	—	benign
rs200457113	1:100,928,200	C/A	—	likely benign
rs2524330554	1:100,928,211	T/A	—	pathogenic
rs770444508	1:100,928,212	C/T	—	uncertain significance
rs373986788	1:100,928,231	C/G	—	uncertain significance
rs1482824856	1:100,928,305	C/T	—	uncertain significance
rs765677912	1:100,928,316	C/T	—	likely benign
rs201560882	1:100,928,321	G/A	—	uncertain significance
rs200624804	1:100,928,347	A/G	—	likely benign
rs61755295	1:100,928,377	G/A	—	benign
rs760951536	1:100,928,379	G/A	—	likely benign
rs770995792	1:100,928,380	C/T	—	pathogenic
rs190052443	1:100,928,381	G/A	—	uncertain significance
rs764506271	1:100,928,391	G/C	—	likely benign
rs138121120	1:100,928,397	C/T	—	likely benign
rs376096146	1:100,928,409	C/T	—	likely benign
rs200731398	1:100,928,410	G/A	—	uncertain significance
rs28364884	1:100,928,418	C/G	—	likely benign
rs74667145	1:100,928,421	C/T	—	benign
rs7543221	1:100,928,424	C/T	—	benign
rs746130734	1:100,928,454	G/A	—	likely benign

Showing 100 of 190 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.