CDK10
cyclin dependent kinase 10
Summary
The protein encoded by this gene belongs to the CDK subfamily of the Ser/Thr protein kinase family. The CDK subfamily members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and are known to be essential for cell cycle progression. This kinase has been shown to play a role in cellular proliferation and its function is limited to cell cycle G2-M phase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
Known Variants83 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs111714972 | 16:89,751,895 | T/C | synonymous variant | — |
| rs397891 | 16:89,753,031 | G/C | regulatory region variant | — |
| rs187319559 | 16:89,753,128 | C/G | — | likely benign |
| rs192221267 | 16:89,753,130 | A/T | — | likely benign |
| rs185587002 | 16:89,753,142 | C/A | — | pathogenic |
| rs188849219 | 16:89,753,143 | G/C | — | uncertain significance |
| rs755709166 | 16:89,753,155 | C/A | — | uncertain significance |
| rs1258010770 | 16:89,753,159 | A/G | — | uncertain significance |
| rs201507040 | 16:89,753,169 | T/G | — | conflicting classifications of pathogenicity |
| rs375838804 | 16:89,753,204 | G/A | — | uncertain significance |
| rs2543559184 | 16:89,753,210 | G/A | — | pathogenic |
| rs12924138 | 16:89,754,444 | G/A | — | — |
| rs2060335629 | 16:89,755,670 | G/A | — | uncertain significance |
| rs755952324 | 16:89,755,673 | G/A | — | uncertain significance |
| rs258322 | 16:89,755,903 | A/T | — | — |
| rs2060398790 | 16:89,756,960 | G/C | — | pathogenic |
| rs141061239 | 16:89,756,969 | C/T | — | uncertain significance |
| rs201199948 | 16:89,756,970 | G/A | — | uncertain significance |
| rs2151571212 | 16:89,757,002 | A/T | — | likely pathogenic |
| rs1323382971 | 16:89,757,008 | G/A | — | uncertain significance |
| rs2543628290 | 16:89,757,026 | A/T | — | pathogenic |
| rs138561644 | 16:89,757,881 | C/G | — | uncertain significance |
| rs1420247770 | 16:89,757,913 | G/C | — | uncertain significance |
| rs2543644323 | 16:89,757,931 | G/A | — | uncertain significance |
| rs143430910 | 16:89,758,285 | C/T | — | uncertain significance |
| rs557111317 | 16:89,758,300 | G/A | — | likely benign |
| rs201827951 | 16:89,758,868 | C/T | — | likely benign |
| rs759397788 | 16:89,758,881 | C/T | — | uncertain significance |
| rs2543666277 | 16:89,758,891 | T/C | — | pathogenic |
| rs2543666566 | 16:89,758,900 | T/C | — | pathogenic |
| rs1233106178 | 16:89,758,913 | C/T | — | likely benign |
| rs199825493 | 16:89,758,931 | G/C | — | likely benign |
| rs187282 | 16:89,758,973 | A/G | — | benign |
| rs951940804 | 16:89,759,710 | A/G | — | uncertain significance |
| rs775505410 | 16:89,759,718 | G/C | missense variant | Likely benign |
| rs141041987 | 16:89,759,723 | G/C | — | uncertain significance |
| rs376029099 | 16:89,759,813 | C/G | — | uncertain significance |
| rs573212914 | 16:89,759,823 | C/T | — | uncertain significance |
| rs779845266 | 16:89,759,837 | C/T | — | likely benign |
| rs564394105 | 16:89,759,850 | A/G | — | uncertain significance |
| rs771066826 | 16:89,759,876 | G/A | — | pathogenic |
| rs460057 | 16:89,760,552 | T/C | — | benign |
| rs1021924129 | 16:89,760,574 | T/G | — | likely benign |
| rs767176610 | 16:89,760,580 | G/A | splice region variant | pathogenic |
| rs1391347309 | 16:89,760,586 | G/A | — | uncertain significance |
| rs749119494 | 16:89,760,607 | G/A | — | uncertain significance |
| rs372466549 | 16:89,760,610 | C/T | — | uncertain significance |
| rs775780737 | 16:89,760,617 | G/A | — | likely benign |
| rs376207812 | 16:89,760,630 | A/G | — | uncertain significance |
| rs145469184 | 16:89,760,633 | G/A | — | uncertain significance |
| rs2543713603 | 16:89,761,073 | G/A | — | likely pathogenic |
| rs753881294 | 16:89,761,088 | A/G | — | uncertain significance |
| rs757456340 | 16:89,761,089 | C/G | — | uncertain significance |
| rs1344821845 | 16:89,761,095 | G/A | — | uncertain significance |
| rs1168984080 | 16:89,761,111 | G/A | — | likely benign |
| rs1381700005 | 16:89,761,121 | C/A | — | likely benign |
| rs1060499745 | 16:89,761,129 | C/G | missense variant | pathogenic |
| rs1303728412 | 16:89,761,196 | G/A | — | pathogenic |
| rs371336768 | 16:89,761,203 | G/A | — | likely benign |
| rs766609467 | 16:89,761,351 | C/G | — | uncertain significance |
| rs374049711 | 16:89,761,379 | G/A | — | uncertain significance |
| rs767833852 | 16:89,761,418 | G/A | — | pathogenic |
| rs2060645101 | 16:89,761,428 | G/T | — | uncertain significance |
| rs907552522 | 16:89,761,432 | G/A | — | uncertain significance |
| rs780139658 | 16:89,761,703 | C/T | — | uncertain significance |
| rs61740483 | 16:89,761,704 | G/A | — | likely benign |
| rs151021544 | 16:89,761,706 | C/T | — | uncertain significance |
| rs141126939 | 16:89,761,710 | C/T | — | likely benign |
| rs2543732022 | 16:89,761,712 | G/A | — | uncertain significance |
| rs370429550 | 16:89,762,051 | G/A | — | uncertain significance |
| rs758922637 | 16:89,762,059 | C/T | — | uncertain significance |
| rs370511293 | 16:89,762,060 | C/A | — | conflicting classifications of pathogenicity |
| rs201210208 | 16:89,762,066 | C/T | — | uncertain significance |
| rs2060691897 | 16:89,762,082 | C/A | — | uncertain significance |
| rs201812075 | 16:89,762,086 | C/T | — | uncertain significance |
| rs772157816 | 16:89,762,087 | G/A | missense variant | pathogenic |
| rs56242003 | 16:89,762,090 | G/A | — | likely benign |
| rs754062493 | 16:89,762,095 | C/A | — | uncertain significance |
| rs562331864 | 16:89,762,099 | G/A | — | likely benign |
| rs146732625 | 16:89,762,136 | G/A | — | uncertain significance |
| rs374856571 | 16:89,762,182 | G/A | — | likely benign |
| rs372178353 | 16:89,762,190 | G/A | — | likely benign |
| rs465552 | 16:89,762,921 | T/C | regulatory region variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.