CDK12

cyclin dependent kinase 12

Summary

Enables RNA polymerase II CTD heptapeptide repeat kinase activity and cyclin binding activity. Involved in several processes, including positive regulation of transcription elongation by RNA polymerase II; protein autophosphorylation; and regulation of MAP kinase activity. Located in nuclear speck. Part of cyclin K-CDK12 complex. Biomarker of gastric adenocarcinoma; hepatocellular carcinoma; and stomach cancer. [provided by Alliance of Genome Resources, Apr 2025]

Known Variants130 total

rsidPosition (GRCh37)AllelesClassClinVar
rs19281984817:37,618,220C/T—benign
rs75319586917:37,618,298T/C—likely benign
rs18369042617:37,618,305T/C—likely benign
rs124675512617:37,618,335C/T—uncertain significance
rs15012440217:37,618,558T/A—likely benign
rs14512353717:37,618,584T/C—uncertain significance
rs14757473217:37,618,591C/T—likely benign
rs14903406417:37,618,595C/T—likely benign
rs76520791717:37,618,673A/G—uncertain significance
rs37758665517:37,618,694A/G—uncertain significance
rs77974249317:37,618,708C/T—likely benign
rs20186406717:37,618,748T/A—uncertain significance
rs128904719317:37,618,868G/A—uncertain significance
rs214489095817:37,618,937G/C—uncertain significance
rs77849374417:37,618,956A/C—uncertain significance
rs75144303217:37,618,983C/G—uncertain significance
rs77018477517:37,618,995A/C—uncertain significance
rs214489486217:37,619,016C/A—uncertain significance
rs3589655017:37,619,038G/A—benign
rs214489810117:37,619,082C/G—uncertain significance
rs122206732917:37,619,131C/T—likely benign
rs76277041717:37,619,183T/C—uncertain significance
rs5640349117:37,619,236C/G—likely benign
rs13876039617:37,619,290A/G—likely benign
rs3425768517:37,621,053A/G——
rs721901417:37,624,790A/T——
rs1107890117:37,625,912C/G——
rs1165789917:37,626,963G/A—benign
rs14424113017:37,627,333T/C—likely benign
rs138599749417:37,627,349G/A—uncertain significance
rs74800967717:37,627,379A/C—uncertain significance
rs5615895417:37,627,387A/G—likely benign
rs37666882317:37,627,472G/A—uncertain significance
rs36827417417:37,627,485A/G—uncertain significance
rs77253861717:37,627,554A/G—uncertain significance
rs20162441717:37,627,598C/T—uncertain significance
rs58777818217:37,627,664C/A—uncertain significance
rs214520325517:37,627,725A/C—uncertain significance
rs89801772417:37,627,790T/C—likely benign
rs74942575117:37,627,900A/G—likely benign
rs14450135217:37,627,940A/G—not provided
rs214521151117:37,627,948C/A—uncertain significance
rs58777818317:37,627,998G/C—uncertain significance
rs1245158517:37,633,831T/G——
rs1245158617:37,633,835T/Adownstream gene variant—
rs1245339717:37,633,970C/Adownstream gene variant—
rs479537117:37,636,695T/A——
rs1245268217:37,646,589T/C—benign
rs14618752617:37,646,763C/T—likely benign
rs14135356017:37,646,866G/A—uncertain significance
rs36842644417:37,646,889C/T—uncertain significance
rs254460467817:37,646,925C/T—uncertain significance
rs205152178617:37,646,935C/T—uncertain significance
rs7282710917:37,647,042T/A—likely benign
rs1294235217:37,648,140G/Cintron variant—
rs18304418517:37,649,204T/G—likely benign
rs1148994217:37,649,419G/T—benign
rs1107890417:37,650,569G/A—benign
rs214591367917:37,650,741C/T—likely benign
rs15059607717:37,650,745T/C—likely benign
rs14472899017:37,651,989G/Tintron variant—
rs131659640317:37,665,974G/A—uncertain significance
rs113169223817:37,665,984G/T—likely pathogenic
rs11256195417:37,666,031A/C—benign
rs37659295317:37,667,702T/C—likely benign
rs37048444817:37,667,770T/A—likely benign
rs479481317:37,670,994A/Tintron variant—
rs807079917:37,671,910A/G—benign
rs807274417:37,672,105A/G—likely benign
rs807127517:37,672,218G/T—benign
rs808152817:37,672,984T/G——
rs55545826217:37,673,645G/C—likely benign
rs15041158117:37,673,738C/A—likely benign
rs230331517:37,673,920T/A—benign
rs3559859717:37,673,942G/A—benign
rs806849717:37,674,061T/C—benign
rs116366987917:37,676,125G/A—likely benign
rs6174741317:37,676,209C/T—likely benign
rs126785749717:37,676,225C/G—uncertain significance
rs92348849617:37,676,262G/A—uncertain significance
rs6174740017:37,676,269G/T—likely benign
rs18349748317:37,676,296C/T—likely benign
rs95959170117:37,676,320C/T—likely benign
rs130210938817:37,676,333C/T—uncertain significance
rs1077539117:37,677,684T/Aintron variant—
rs14401184317:37,681,117T/C—likely benign
rs37215914717:37,681,133C/T—uncertain significance
rs806596317:37,681,332C/T—benign
rs5963611517:37,682,001C/T—benign
rs36784583917:37,682,091A/G—likely benign
rs11248780717:37,682,124T/C—likely benign
rs6174743017:37,682,200A/G—likely benign
rs1295078417:37,682,292G/A—benign
rs254537135917:37,682,315A/T—uncertain significance
rs254537183717:37,682,329G/T—uncertain significance
rs5636216517:37,682,375T/G—uncertain significance
rs58777817717:37,682,378C/G—uncertain significance
rs6174161517:37,682,393C/T—likely benign
rs77784484117:37,682,416C/T—uncertain significance
rs74716686017:37,682,425A/G—uncertain significance

Showing 100 of 130 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.