CIT

citron rho-interacting serine/threonine kinase

Summary

This gene encodes a serine/threonine-protein kinase that functions in cell division. Together with the kinesin KIF14, this protein localizes to the central spindle and midbody, and functions to promote efficient cytokinesis. This protein is involved in central nervous system development. Polymorphisms in this gene are associated with bipolar disorder and risk for schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]

Known Variants527 total

rsidPosition (GRCh37)AllelesClassClinVar
rs250068740012:120,126,055C/A—uncertain significance
rs5621278212:120,126,058G/C—likely benign
rs148931518312:120,126,064G/A—likely benign
rs18862930412:120,126,084G/A—likely benign
rs11135625012:120,127,735C/T—likely benign
rs14868602412:120,127,748T/C—likely benign
rs14224030112:120,127,940C/T—benign
rs250071810512:120,127,956C/T—uncertain significance
rs74979655512:120,127,972A/G—uncertain significance
rs76413734312:120,127,985C/T—uncertain significance
rs57484594612:120,127,986G/A—likely benign
rs1154711812:120,127,993G/T—uncertain significance
rs77993558312:120,128,005C/A—uncertain significance
rs148226612712:120,128,042G/A—uncertain significance
rs15077053912:120,128,082T/C—benign
rs76644520412:120,128,091G/A—likely benign
rs148669072612:120,128,117G/A—uncertain significance
rs20078733712:120,128,143C/T—uncertain significance
rs36817006712:120,128,155C/T—uncertain significance
rs250072365412:120,128,162C/G—uncertain significance
rs128542990912:120,128,173C/T—uncertain significance
rs13912134112:120,128,187C/A—benign
rs130116529712:120,128,226G/A—likely benign
rs137983373212:120,128,278C/T—likely benign
rs11561856412:120,135,330G/A—benign
rs77536973712:120,135,467C/T—uncertain significance
rs3543123712:120,135,478C/T—benign
rs75680715812:120,135,485C/T—uncertain significance
rs20113953812:120,135,496A/C—likely benign
rs141554073412:120,135,498T/C—uncertain significance
rs56642726512:120,135,514G/A—benign
rs14783831312:120,135,517G/A—likely benign
rs103529692812:120,135,539C/G—uncertain significance
rs79605216112:120,135,560G/T—uncertain significance
rs77638336912:120,135,563G/A—uncertain significance
rs76467417112:120,135,574C/T—likely benign
rs36757301512:120,135,613C/T—likely benign
rs27812612:120,135,717G/T—benign
rs76231508212:120,135,856T/C—uncertain significance
rs11511132612:120,135,882C/T—likely benign
rs6083125712:120,135,929T/C—benign
rs14447522112:120,136,120C/T—likely benign
rs18887605212:120,138,299T/G—likely benign
rs6075497612:120,138,306G/A—benign
rs7955360312:120,138,525A/G—likely benign
rs1161027812:120,138,541T/C—benign
rs213697922312:120,138,560A/C—likely benign
rs36898195712:120,138,583C/T—uncertain significance
rs77818733712:120,138,592G/A—uncertain significance
rs74983611112:120,138,597C/T—uncertain significance
rs37347875512:120,138,605G/A—likely benign
rs7685035812:120,138,679G/C—benign
rs14364752212:120,138,853A/G—benign
rs973824212:120,138,865G/A—benign
rs7842499312:120,139,106G/C—likely benign
rs5802689112:120,139,245C/G—benign
rs76528374312:120,139,413C/A—likely benign
rs13816161012:120,139,433G/T—uncertain significance
rs139123131212:120,139,456G/A—pathogenic
rs14915899112:120,139,465C/T—likely benign
rs56729815512:120,139,466G/A—likely benign
rs76892450112:120,139,480C/T—uncertain significance
rs75835870112:120,139,511G/A—likely benign
rs94793049512:120,139,525G/A—uncertain significance
rs75088044112:120,139,561T/C—likely benign
rs11431576212:120,139,633C/T—likely benign
rs77903456512:120,139,659G/T—likely benign
rs18071647412:120,139,663G/A—uncertain significance
rs75997668212:120,139,685C/G—uncertain significance
rs3414035712:120,139,701T/G—benign
rs3515481512:120,139,752G/T—likely benign
rs11525717712:120,139,871T/C—likely benign
rs14111099412:120,139,974A/G—likely benign
rs7657990412:120,141,906G/A—likely benign
rs7341218212:120,142,124G/T—likely benign
rs74677235912:120,142,178C/G—uncertain significance
rs250085123112:120,142,193T/G—uncertain significance
rs78098173912:120,142,198G/A—likely benign
rs115658528412:120,142,216G/A—likely benign
rs56189435512:120,142,234T/G—likely benign
rs37397527812:120,142,266A/G—conflicting classifications of pathogenicity
rs7733481112:120,142,365C/A—benign
rs6029538412:120,142,483C/T—benign
rs7985192712:120,145,663C/G—benign
rs5615804612:120,145,987G/C—benign
rs5616778112:120,146,026A/T—benign
rs5630349712:120,146,028T/C—benign
rs142904649412:120,146,030T/C—uncertain significance
rs37314991912:120,146,043C/T—uncertain significance
rs74871760812:120,146,044G/A—likely benign
rs5614633412:120,146,083C/T—benign
rs20086248712:120,146,129C/A—benign
rs7958123212:120,146,164G/A—likely benign
rs7341218912:120,146,292T/A—benign
rs18835876612:120,146,301A/T—benign
rs5607984712:120,146,352A/G—benign
rs14907619612:120,147,992C/T—likely benign
rs37714937912:120,148,049C/T—likely benign
rs159342822512:120,148,080G/T—uncertain significance
rs77626807112:120,148,092T/C—uncertain significance

Showing 100 of 527 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.