rs278126
This variant is located in the CIT gene.
▶ClinVar annotation
▶Research that mentions this SNP (1)
▶Evidence of statistical epistasis between DISC1, CIT and NDEL1 impacting risk for schizophrenia: biological validation with functional neuroimagingAssociationN=648Kristin K. Nicodemus et al.(2010)· Human Genetics
This case-control association study identified statistical epistasis between SNPs in DISC1, CIT, and NDEL1 genes impacting schizophrenia risk (N=289 cases, 359 controls). Four significant two-SNP interactions were detected: NDEL1 rs4791707-CIT rs10744743 (OR=4.44, p=0.00013, Bonferroni-corrected); DISC1 rs1411771-CIT rs10744743 (OR=3.07, p=0.007); CIT rs3847960-CIT rs203332 (OR=2.90, p=0.003); CIT rs3847960-CIT rs440299 (OR=2.16, p=0.038). Three of four interactions were biologically validated via fMRI in an independent healthy control sample (N=217-260), showing that risk-associated genotype combinations predicted prefrontal cortical inefficiency during working memory tasks.
About CIT
This gene encodes a serine/threonine-protein kinase that functions in cell division. Together with the kinesin KIF14, this protein localizes to the central spindle and midbody, and functions to promote efficient cytokinesis. This protein is involved in central nervous system development. Polymorphisms in this gene are associated with bipolar disorder and risk for schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
View all CIT variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
Community Wiki
No community notes yet for this variant. Sign in to start one.
Comments
Sign in to join the discussion.
Loading comments…