CLYBL

citramalyl-CoA lyase

Summary

Enables (S)-citramalyl-CoA lyase activity; magnesium ion binding activity; and malate synthase activity. Involved in protein homotrimerization and regulation of cobalamin metabolic process. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Known Variants35 total

rsidPosition (GRCh37)AllelesClassClinVar
rs75668566013:100,258,954C/Guncertain significance
rs86584050813:100,258,959C/Tuncertain significance
rs18457017813:100,258,980C/Guncertain significance
rs75929060213:100,258,987C/Tuncertain significance
rs76263658213:100,258,998G/Auncertain significance
rs20002059513:100,258,999C/Tuncertain significance
rs37081373313:100,259,001C/Guncertain significance
rs456443713:100,288,789G/A
rs215367213:100,300,942C/Tintron variant
rs37261252713:100,425,149G/Auncertain significance
rs74694298213:100,425,232G/Tuncertain significance
rs13804298713:100,444,738G/Aintron variant
rs951367513:100,493,160G/Aintron variant
rs144083211813:100,511,125G/Auncertain significance
rs77051787113:100,511,145C/Guncertain significance
rs20122310813:100,511,245G/Auncertain significance
rs148974816613:100,511,272C/Guncertain significance
rs13905436113:100,512,268C/Tregulatory region variant
rs141896402113:100,517,096G/Alikely benign
rs146051882413:100,517,123G/Cuncertain significance
rs96012927513:100,517,132G/Auncertain significance
rs129195771613:100,517,154G/Auncertain significance
rs37384020013:100,518,502A/Guncertain significance
rs75717680813:100,518,515C/Auncertain significance
rs77146000313:100,518,554T/Cuncertain significance
rs4128111213:100,518,634C/Tstop gained
rs54041757513:100,518,635G/Auncertain significance
rs14737016213:100,518,646G/Auncertain significance
rs76325537113:100,518,650T/Cuncertain significance
rs955732113:100,521,101T/Cintron variant
rs54103802213:100,523,268G/Cuncertain significance
rs250284949413:100,543,603A/Tuncertain significance
rs14892137913:100,543,639C/Tuncertain significance
rs951790813:100,549,885G/Adownstream gene variant
rs799264313:100,555,038G/Cintergenic variant

Gene information from NCBI Gene. Variant classifications from ClinVar.