rs9517908
This is a downstream gene variant variant in the CLYBL gene.
▶GWAS Catalog Trait Associations (4)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (4)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
smoking initiation
Saunders GRB et al. “Genetic diversity fuels gene discovery for tobacco and alcohol use.” Nature 612(7941):720-724 (2022)
Allele A
OR 0.01
p 7.0e-40
N 3,382,012
Large GWAS
European, East Asian, Hispanic or Latin American, African unspecified
Xu K et al. “Genome-wide association study of smoking trajectory and meta-analysis of smoking status in 842,000 individuals.” Nature Communications 11(1):5302 (2020)
Allele A
OR 1.02
p 4.0e-9
N 842,717
Meta-analysisLarge GWAS
European
social inhibition quality, attention deficit hyperactivity disorder, substance abuse
Karlsson Linnér R et al. “Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction.” Nature Neuroscience 24(10):1367-1376 (2021)
Allele G
OR 0.01
p 6.0e-12
N 2,776,348
Large GWAS
European
body mass index
Jee YH et al. “Genome-wide association studies in a large Korean cohort identify quantitative trait loci for 36 traits and illuminate their genetic architectures.” Nature Communications 16(1):4935 (2025)
Allele G
OR 0.02
p 1.0e-8
N 153,950
Large GWAS
East Asian
biological sex
Pirastu N et al. “Genetic analyses identify widespread sex-differential participation bias.” Nature Genetics 53(5):663-671 (2021)
Allele G
OR 0.01
p 3.0e-8
N 2,462,132
Large GWAS
European
About CLYBL
Enables (S)-citramalyl-CoA lyase activity; magnesium ion binding activity; and malate synthase activity. Involved in protein homotrimerization and regulation of cobalamin metabolic process. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]
View all CLYBL variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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