CNR1

cannabinoid receptor 1

Summary

This gene encodes one of two cannabinoid receptors. The cannabinoids, principally delta-9-tetrahydrocannabinol and synthetic analogs, are psychoactive ingredients of marijuana. The cannabinoid receptors are members of the guanine-nucleotide-binding protein (G-protein) coupled receptor family, which inhibit adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner. The two receptors have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. Multiple transcript variants encoding two different protein isoforms have been described for this gene. [provided by RefSeq, May 2009]

Known Variants38 total

rsidPosition (GRCh37)AllelesClassClinVar
rs8063686:88,850,100T/C3 prime UTR variant—
rs127200716:88,851,181T/C3 prime UTR variant—
rs1999422656:88,853,593C/T—likely benign
rs10493536:88,853,635C/Tsynonymous variant—
rs7724928946:88,853,658C/T—uncertain significance
rs7584136056:88,853,669A/C—uncertain significance
rs2020706516:88,853,863C/A—likely benign
rs24818914006:88,853,865T/C—uncertain significance
rs1479974216:88,853,902C/T—likely benign
rs11999600696:88,853,942A/G—uncertain significance
rs7771293556:88,853,943C/A—uncertain significance
rs2012185086:88,854,079G/C—likely benign
rs1442339636:88,854,082G/A—benign
rs7795167876:88,854,123C/G—uncertain significance
rs7626432356:88,854,250G/A—likely benign
rs15823254736:88,854,313A/T—likely benign
rs1379072326:88,854,514C/T—likely benign
rs3681997046:88,854,525C/T—uncertain significance
rs7806080746:88,854,561G/T—uncertain significance
rs5324777926:88,854,733C/T—likely benign
rs1458557706:88,854,738G/A—uncertain significance
rs7678107736:88,854,803G/A—uncertain significance
rs1914583196:88,854,809A/G—uncertain significance
rs1387535236:88,854,883C/T—uncertain significance
rs2002205856:88,854,964A/G—likely benign
rs8063746:88,857,320T/Cintron variant—
rs8063776:88,858,723T/A——
rs8063786:88,859,551C/T5 prime UTR variant—
rs20232396:88,860,482T/C5 prime UTR variant—
rs15352556:88,861,208T/Gupstream gene variant—
rs8063796:88,861,267A/Tupstream gene variant—
rs69284996:88,861,289G/Cupstream gene variant—
rs64546726:88,861,570T/Cupstream gene variant—
rs94508986:88,864,063C/Tupstream gene variant—
rs8063806:88,864,653A/Gupstream gene variant—
rs8063816:88,865,901A/Gintron variant—
rs64546746:88,872,930T/Gintron variant—
rs21806196:88,877,952G/Aupstream gene variant—

Gene information from NCBI Gene. Variant classifications from ClinVar.