COMMD7
COMM domain containing 7
Summary
Enables NF-kappaB binding activity. Involved in negative regulation of DNA-templated transcription; negative regulation of NF-kappaB transcription factor activity; and tumor necrosis factor-mediated signaling pathway. Predicted to be located in cytoplasmic vesicle and membrane. [provided by Alliance of Genome Resources, Jul 2025]
Known Variants23 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs376710761 | 20:31,291,249 | G/A | — | uncertain significance |
| rs61684036 | 20:31,291,822 | C/T | — | benign |
| rs781670155 | 20:31,291,840 | C/T | — | uncertain significance |
| rs2515106896 | 20:31,291,848 | T/C | — | uncertain significance |
| rs371047702 | 20:31,291,851 | C/A | — | uncertain significance |
| rs200530368 | 20:31,292,247 | A/C | — | uncertain significance |
| rs769518564 | 20:31,292,681 | G/A | — | uncertain significance |
| rs543076276 | 20:31,292,700 | G/T | — | uncertain significance |
| rs781297062 | 20:31,294,402 | T/C | — | uncertain significance |
| rs750395324 | 20:31,294,523 | G/A | — | uncertain significance |
| rs28439340 | 20:31,299,723 | G/A | intron variant | — |
| rs1314782903 | 20:31,315,745 | C/A | — | uncertain significance |
| rs1485113530 | 20:31,315,765 | G/A | — | uncertain significance |
| rs2515220441 | 20:31,315,906 | T/C | — | uncertain significance |
| rs2515220529 | 20:31,315,913 | G/C | — | uncertain significance |
| rs777352425 | 20:31,315,939 | G/T | — | uncertain significance |
| rs6119942 | 20:31,321,158 | C/T | intron variant | — |
| rs8116188 | 20:31,321,920 | A/G | intron variant | — |
| rs11698914 | 20:31,327,144 | C/G | intron variant | — |
| rs11699342 | 20:31,327,332 | C/A | — | — |
| rs6057634 | 20:31,327,650 | G/C | — | — |
| rs13038397 | 20:31,329,949 | C/T | intron variant | — |
| rs996639002 | 20:31,331,127 | T/C | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.