COP1
COP1 E3 ubiquitin ligase
Summary
Enables ubiquitin protein ligase activity. Involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process; proteasome-mediated ubiquitin-dependent protein catabolic process; and response to ionizing radiation. Part of Cul4A-RING E3 ubiquitin ligase complex. [provided by Alliance of Genome Resources, Jul 2025]
Known Variants44 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs976102957 | 1:175,916,369 | T/G | — | uncertain significance |
| rs1571414351 | 1:175,956,103 | C/T | — | likely benign |
| rs1464569267 | 1:175,956,169 | A/T | — | uncertain significance |
| rs557783032 | 1:175,957,433 | T/C | — | uncertain significance |
| rs201905141 | 1:175,957,444 | T/C | — | uncertain significance |
| rs749820946 | 1:175,958,570 | A/C | — | uncertain significance |
| rs111531372 | 1:175,958,578 | T/C | — | benign |
| rs35846379 | 1:175,968,013 | G/C | — | — |
| rs184147074 | 1:175,974,794 | G/A | intron variant | — |
| rs1041415266 | 1:176,012,392 | C/T | — | likely benign |
| rs1452611461 | 1:176,012,893 | C/T | — | uncertain significance |
| rs1298887687 | 1:176,015,440 | C/T | — | uncertain significance |
| rs78275727 | 1:176,027,200 | G/A | intron variant | — |
| rs1180942548 | 1:176,050,309 | T/C | — | uncertain significance |
| rs148950158 | 1:176,050,414 | C/T | — | uncertain significance |
| rs879019998 | 1:176,050,430 | G/A | — | likely benign |
| rs557168088 | 1:176,050,431 | A/G | — | likely benign |
| rs2546743244 | 1:176,054,914 | G/A | — | uncertain significance |
| rs2546745262 | 1:176,055,023 | T/C | — | uncertain significance |
| rs1162820625 | 1:176,085,790 | G/T | — | uncertain significance |
| rs745481639 | 1:176,085,803 | G/T | — | uncertain significance |
| rs2547177560 | 1:176,104,203 | G/C | — | uncertain significance |
| rs41266110 | 1:176,104,219 | T/C | — | benign |
| rs75124417 | 1:176,105,631 | C/G | — | benign |
| rs2547190208 | 1:176,105,652 | A/T | — | uncertain significance |
| rs146447727 | 1:176,110,620 | G/C | regulatory region variant | — |
| rs1692011237 | 1:176,118,186 | T/C | — | uncertain significance |
| rs139373171 | 1:176,118,187 | C/G | — | likely benign |
| rs1385240828 | 1:176,132,021 | T/C | — | uncertain significance |
| rs1330861874 | 1:176,132,106 | T/C | — | uncertain significance |
| rs370091759 | 1:176,132,994 | A/G | — | uncertain significance |
| rs138668228 | 1:176,145,082 | C/T | — | uncertain significance |
| rs12755507 | 1:176,164,865 | T/C | intron variant | — |
| rs772231273 | 1:176,175,723 | C/T | — | uncertain significance |
| rs779964540 | 1:176,175,765 | G/A | — | uncertain significance |
| rs1344482634 | 1:176,175,828 | C/G | — | uncertain significance |
| rs778706741 | 1:176,175,864 | G/A | — | uncertain significance |
| rs769118592 | 1:176,175,913 | C/T | — | uncertain significance |
| rs1700910285 | 1:176,175,927 | C/T | — | uncertain significance |
| rs2547695555 | 1:176,175,933 | A/C | — | uncertain significance |
| rs765186257 | 1:176,176,014 | G/A | — | uncertain significance |
| rs528847290 | 1:176,176,071 | C/T | — | uncertain significance |
| rs751499796 | 1:176,176,084 | A/T | — | uncertain significance |
| rs893191628 | 1:176,176,095 | G/A | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.