CXCL13
C-X-C motif chemokine ligand 13
Summary
B lymphocyte chemoattractant, independently cloned and named Angie, is an antimicrobial peptide and CXC chemokine strongly expressed in the follicles of the spleen, lymph nodes, and Peyer's patches. It preferentially promotes the migration of B lymphocytes (compared to T cells and macrophages), apparently by stimulating calcium influx into, and chemotaxis of, cells expressing Burkitt's lymphoma receptor 1 (BLR-1). It may therefore function in the homing of B lymphocytes to follicles. [provided by RefSeq, Oct 2014]
Known Variants5 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs7685785 | 4:78,440,425 | C/T | intron variant | — |
| rs355689 | 4:78,507,797 | T/A | — | — |
| rs117605225 | 4:78,508,197 | T/G | regulatory region variant | — |
| rs367546065 | 4:78,528,959 | G/A | — | uncertain significance |
| rs768499587 | 4:78,532,183 | A/G | — | likely benign |
Gene information from NCBI Gene. Variant classifications from ClinVar.