rs355689

This variant is located in the CXCL13 gene.

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Research that mentions this SNP (1)

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CXCR5 polymorphisms in non-Hodgkin lymphoma risk and prognosis
AssociationN=4,215Bridget Charbonneau et al.(2013)· Cancer Immunology, Immunotherapy

A clinic-based case-control study of 2,694 NHL cases and 1,521 controls found that five of ten CXCR5 tag SNPs were associated with non-Hodgkin lymphoma risk, with rs1790192 showing the strongest association (increased risk of follicular lymphoma). Paradoxically, rs1790192 was also associated with superior event-free survival in follicular lymphoma patients, suggesting different roles of CXCR5 in lymphoma initiation versus progression.

Traits studied:Chronic lymphocytic leukemiaDiffuse large B-cell lymphomaFollicular lymphomaMantle cell lymphomaMarginal zone lymphomaNon-Hodgkin lymphomaPeripheral T-cell lymphomaSmall lymphocytic lymphoma
PubMedDOIMetascience Observatory

About CXCL13

B lymphocyte chemoattractant, independently cloned and named Angie, is an antimicrobial peptide and CXC chemokine strongly expressed in the follicles of the spleen, lymph nodes, and Peyer's patches. It preferentially promotes the migration of B lymphocytes (compared to T cells and macrophages), apparently by stimulating calcium influx into, and chemotaxis of, cells expressing Burkitt's lymphoma receptor 1 (BLR-1). It may therefore function in the homing of B lymphocytes to follicles. [provided by RefSeq, Oct 2014]

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Gene information from NCBI Gene. Variant classifications from ClinVar.

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