CXCR2

C-X-C motif chemokine receptor 2

Summary

The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2009]

Known Variants183 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs3890158	2:218,990,292	G/A	—	—
rs4674258	2:218,990,586	C/T	regulatory region variant	—
rs4674259	2:218,991,005	G/A	5 prime UTR variant	—
rs6723449	2:218,997,580	T/C	intron variant	—
rs17844697	2:218,999,255	G/A	—	benign
rs139809702	2:218,999,541	T/G	—	likely benign
rs201134932	2:218,999,542	G/A	—	uncertain significance
rs776173448	2:218,999,551	C/T	—	likely benign
rs1225234360	2:218,999,556	T/C	—	uncertain significance
rs371161134	2:218,999,561	G/C	—	uncertain significance
rs55672388	2:218,999,567	T/C	—	uncertain significance
rs561614631	2:218,999,585	A/C	—	uncertain significance
rs2469113212	2:218,999,591	T/G	—	uncertain significance
rs200836817	2:218,999,599	C/T	—	likely benign
rs952339154	2:218,999,602	C/T	—	likely benign
rs1222581924	2:218,999,608	C/T	—	likely benign
rs148935180	2:218,999,611	G/T	—	likely benign
rs142762038	2:218,999,614	C/G	—	likely benign
rs1280319953	2:218,999,616	C/A	—	uncertain significance
rs532069369	2:218,999,618	T/G	—	uncertain significance
rs201373363	2:218,999,632	C/T	—	likely benign
rs75759064	2:218,999,633	G/A	—	uncertain significance
rs2106107764	2:218,999,636	C/T	—	uncertain significance
rs1690743201	2:218,999,638	A/G	—	likely benign
rs200402782	2:218,999,643	A/G	—	uncertain significance
rs1233080228	2:218,999,664	A/G	—	uncertain significance
rs141285974	2:218,999,665	C/T	—	likely benign
rs756891890	2:218,999,670	A/G	—	uncertain significance
rs780729371	2:218,999,672	T/C	—	uncertain significance
rs1434816450	2:218,999,677	G/C	—	likely benign
rs1369278347	2:218,999,683	T/C	—	likely benign
rs199770538	2:218,999,688	A/T	—	uncertain significance
rs2469113590	2:218,999,696	G/A	—	uncertain significance
rs2106107866	2:218,999,704	G/C	—	likely benign
rs11574748	2:218,999,705	C/T	—	likely benign
rs1294172370	2:218,999,709	G/A	—	uncertain significance
rs534692959	2:218,999,713	G/T	—	likely benign
rs762103956	2:218,999,714	C/A	—	uncertain significance
rs201294973	2:218,999,728	C/T	—	likely benign
rs2469113679	2:218,999,745	T/C	—	uncertain significance
rs199633255	2:218,999,747	T/C	—	uncertain significance
rs2469113776	2:218,999,752	C/G	—	uncertain significance
rs2469113797	2:218,999,756	G/A	—	uncertain significance
rs150483744	2:218,999,758	C/T	—	likely benign
rs149364972	2:218,999,759	G/A	—	likely benign
rs138773569	2:218,999,762	C/T	—	benign
rs372364370	2:218,999,767	C/A	—	likely benign
rs201754155	2:218,999,768	G/A	—	uncertain significance
rs769234467	2:218,999,785	G/A	—	likely benign
rs200819332	2:218,999,794	A/G	—	likely benign
rs752383293	2:218,999,795	G/A	—	uncertain significance
rs199535002	2:218,999,796	C/T	—	uncertain significance
rs142747099	2:218,999,798	T/C	—	likely benign
rs759645813	2:218,999,805	A/G	—	uncertain significance
rs1449221105	2:218,999,818	C/T	—	likely benign
rs763954636	2:218,999,824	C/T	—	likely benign
rs1462610962	2:218,999,827	G/A	—	likely benign
rs761868394	2:218,999,839	C/T	—	likely benign
rs1014647889	2:218,999,840	G/A	—	uncertain significance
rs2469114142	2:218,999,858	T/C	—	uncertain significance
rs2469114159	2:218,999,860	G/T	—	uncertain significance
rs147368052	2:218,999,872	A/G	—	benign
rs2469114287	2:218,999,910	A/G	—	uncertain significance
rs748602418	2:218,999,911	C/T	—	likely benign
rs756075992	2:218,999,918	A/C	—	uncertain significance
rs1417138569	2:218,999,940	G/A	—	uncertain significance
rs141722043	2:218,999,954	C/T	—	uncertain significance
rs759555888	2:218,999,955	G/A	—	uncertain significance
rs2469114523	2:218,999,977	C/T	—	likely benign
rs767538305	2:218,999,981	C/T	—	uncertain significance
rs55799208	2:218,999,982	G/A	—	conflicting classifications of pathogenicity
rs766059153	2:218,999,985	C/T	—	uncertain significance
rs146545386	2:218,999,995	G/A	—	likely benign
rs1574542732	2:218,999,996	A/T	—	likely pathogenic
rs200940650	2:218,999,999	C/T	—	uncertain significance
rs368809767	2:219,000,000	G/T	—	uncertain significance
rs202076117	2:219,000,006	T/G	—	uncertain significance
rs1574542767	2:219,000,012	A/T	—	uncertain significance
rs200386344	2:219,000,025	C/T	—	likely benign
rs912436713	2:219,000,028	C/T	—	likely benign
rs1690759254	2:219,000,036	G/A	—	uncertain significance
rs1053698644	2:219,000,048	T/A	—	uncertain significance
rs199906283	2:219,000,050	C/T	—	likely benign
rs201535541	2:219,000,052	G/T	—	likely benign
rs1400752078	2:219,000,053	G/A	—	uncertain significance
rs201960181	2:219,000,055	C/T	—	likely benign
rs749406301	2:219,000,058	G/C	—	likely benign
rs2469114935	2:219,000,073	C/T	—	likely benign
rs200409575	2:219,000,074	C/T	—	pathogenic
rs199777583	2:219,000,083	G/A	—	uncertain significance
rs2469114997	2:219,000,093	C/T	—	uncertain significance
rs573773779	2:219,000,096	A/G	—	uncertain significance
rs757932890	2:219,000,097	T/C	—	likely benign
rs200413041	2:219,000,108	C/A	—	likely benign
rs940986368	2:219,000,115	T/C	—	likely benign
rs201063764	2:219,000,118	G/A	—	likely benign
rs2469115072	2:219,000,121	C/T	—	likely benign
rs199692849	2:219,000,127	C/A	—	likely benign
rs1473048332	2:219,000,135	C/T	—	uncertain significance
rs2469115140	2:219,000,143	T/A	—	uncertain significance

Showing 100 of 183 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.