DCAF1
DDB1 and CUL4 associated factor 1
Summary
Enables histone H2AT120 kinase activity; nuclear estrogen receptor binding activity; and ubiquitin-like ligase-substrate adaptor activity. Involved in several processes, including cell competition in a multicellular organism; proteasome-mediated ubiquitin-dependent protein catabolic process; and regulation of primary metabolic process. Located in COP9 signalosome; fibrillar center; and nucleoplasm. Part of Cul4-RING E3 ubiquitin ligase complex. Is active in centrosome. [provided by Alliance of Genome Resources, Jul 2025]
Known Variants8 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs2470919716 | 3:51,440,695 | A/G | — | likely benign |
| rs529977296 | 3:51,447,104 | C/T | — | — |
| rs150385433 | 3:51,458,204 | G/A | — | likely benign |
| rs146381464 | 3:51,463,177 | C/A | intron variant | — |
| rs146370649 | 3:51,468,766 | C/G | upstream gene variant | — |
| rs35971989 | 3:51,469,248 | A/G | upstream gene variant | — |
| rs62257549 | 3:51,522,676 | G/A | intron variant | — |
| rs184102325 | 3:51,526,168 | G/A | intron variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.