DCDC2

doublecortin domain containing 2

Summary

This gene encodes a doublecortin domain-containing family member. The doublecortin domain has been demonstrated to bind tubulin and enhance microtubule polymerization. This family member is thought to function in neuronal migration where it may affect the signaling of primary cilia. Mutations in this gene have been associated with reading disability (RD) type 2, also referred to as developmental dyslexia. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2013]

Known Variants242 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs16888768	6:24,174,674	A/G	—	benign
rs7744665	6:24,174,803	A/C	—	benign
rs7764902	6:24,174,834	T/A	—	benign
rs1760863057	6:24,174,948	T/C	—	likely benign
rs9358755	6:24,174,955	G/A	—	likely benign
rs145154884	6:24,174,966	C/T	—	conflicting classifications of pathogenicity
rs146868469	6:24,174,967	G/A	—	likely benign
rs1341118731	6:24,174,983	T/G	—	uncertain significance
rs1561877167	6:24,174,999	C/T	—	uncertain significance
rs1253412168	6:24,175,011	G/A	—	uncertain significance
rs9460973	6:24,175,021	T/A	—	benign
rs763350514	6:24,175,025	A/G	—	uncertain significance
rs374448795	6:24,175,030	T/C	—	conflicting classifications of pathogenicity
rs1042335474	6:24,175,033	C/T	—	uncertain significance
rs2480848964	6:24,175,041	G/T	—	uncertain significance
rs368603558	6:24,175,045	T/C	—	likely benign
rs1301344173	6:24,175,047	G/T	—	uncertain significance
rs77929453	6:24,175,071	A/G	—	likely benign
rs751249656	6:24,175,073	A/G	—	conflicting classifications of pathogenicity
rs1027558772	6:24,175,077	A/T	—	conflicting classifications of pathogenicity
rs3789219	6:24,175,124	C/T	—	benign
rs6907583	6:24,175,319	A/G	—	benign
rs16888787	6:24,175,380	C/G	—	likely benign
rs1419228	6:24,178,306	G/A	intron variant	benign
rs78242664	6:24,178,499	G/A	—	benign
rs752452396	6:24,178,549	T/C	—	likely benign
rs751396384	6:24,178,566	G/A	—	uncertain significance
rs201830443	6:24,178,570	A/G	—	uncertain significance
rs1480906981	6:24,178,571	C/A	—	uncertain significance
rs781230955	6:24,178,596	C/T	—	uncertain significance
rs375119774	6:24,178,601	T/A	—	uncertain significance
rs534996877	6:24,178,609	C/A	—	likely benign
rs755258271	6:24,178,612	T/C	—	likely benign
rs794729665	6:24,178,613	T/G	missense variant	pathogenic
rs773832570	6:24,178,643	T/G	—	uncertain significance
rs771499861	6:24,178,647	C/T	—	uncertain significance
rs763861048	6:24,178,660	G/T	—	likely benign
rs1367144327	6:24,178,661	G/A	—	uncertain significance
rs567036123	6:24,178,663	G/C	—	likely benign
rs149268081	6:24,178,664	C/A	—	uncertain significance
rs756047736	6:24,178,665	C/G	—	uncertain significance
rs1561878667	6:24,178,667	C/T	—	uncertain significance
rs754991150	6:24,178,672	T/G	—	likely benign
rs139858268	6:24,178,676	C/T	—	likely benign
rs1244351893	6:24,178,677	G/A	—	uncertain significance
rs143452599	6:24,178,681	A/T	—	likely benign
rs771591530	6:24,178,685	C/T	—	conflicting classifications of pathogenicity
rs2480853462	6:24,178,707	C/A	—	uncertain significance
rs761388263	6:24,178,719	C/T	—	uncertain significance
rs767129413	6:24,178,720	G/A	—	likely benign
rs773020868	6:24,178,730	G/A	—	uncertain significance
rs180988889	6:24,178,737	C/G	—	likely benign
rs1228097560	6:24,178,747	C/T	—	likely benign
rs986382887	6:24,178,748	C/T	—	uncertain significance
rs778095991	6:24,178,776	T/C	—	uncertain significance
rs752022886	6:24,178,782	C/T	—	uncertain significance
rs757670255	6:24,178,784	G/A	—	uncertain significance
rs538198742	6:24,178,785	A/T	—	conflicting classifications of pathogenicity
rs1393437679	6:24,178,808	T/A	—	uncertain significance
rs746347880	6:24,178,813	G/T	—	uncertain significance
rs183480366	6:24,178,818	C/T	—	conflicting classifications of pathogenicity
rs747652700	6:24,178,828	A/C	—	uncertain significance
rs143313706	6:24,178,840	G/A	—	likely benign
rs766600237	6:24,178,856	G/A	—	uncertain significance
rs753636454	6:24,178,860	T/A	—	uncertain significance
rs754765133	6:24,178,876	G/A	—	likely benign
rs75899525	6:24,178,887	A/G	—	benign
rs11754435	6:24,178,998	C/T	—	benign
rs1340694	6:24,178,999	G/A	—	benign
rs2282374	6:24,179,061	C/G	—	benign
rs2027584	6:24,191,459	G/C	—	—
rs6938792	6:24,203,535	C/A	intron variant	—
rs6906832	6:24,204,985	A/G	—	benign
rs78262046	6:24,205,202	C/G	—	likely benign
rs1237059249	6:24,205,216	G/T	—	likely benign
rs2532262469	6:24,205,219	A/G	—	likely benign
rs1303974976	6:24,205,221	G/A	—	uncertain significance
rs1389720008	6:24,205,235	C/T	—	uncertain significance
rs9467075	6:24,205,236	G/A	synonymous variant	benign
rs187789776	6:24,205,244	C/G	—	uncertain significance
rs1561889345	6:24,205,254	A/C	—	conflicting classifications of pathogenicity
rs2532262578	6:24,205,261	T/A	—	uncertain significance
rs1314300838	6:24,205,270	T/C	—	uncertain significance
rs1408902119	6:24,205,275	T/G	—	uncertain significance
rs1416369642	6:24,205,283	C/A	—	uncertain significance
rs146587418	6:24,205,286	C/G	—	uncertain significance
rs77150627	6:24,205,288	C/G	—	uncertain significance
rs140084657	6:24,205,299	C/T	—	conflicting classifications of pathogenicity
rs746447569	6:24,205,324	C/G	—	uncertain significance
rs756932116	6:24,205,329	A/G	—	likely benign
rs1313039709	6:24,205,338	G/C	—	uncertain significance
rs745691985	6:24,205,340	C/A	—	likely benign
rs200973005	6:24,205,342	A/C	—	likely benign
rs768651764	6:24,205,348	C/T	—	likely benign
rs6907894	6:24,205,464	C/A	—	benign
rs112575643	6:24,205,469	T/G	—	likely benign
rs192099171	6:24,205,475	G/A	—	likely benign
rs34570685	6:24,205,649	A/C	—	likely benign
rs793862	6:24,207,200	A/G	intron variant	—
rs9467076	6:24,209,255	T/C	intron variant	—

Showing 100 of 242 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.