DENND4A
DENN domain containing 4A
Summary
This gene encodes a DENN domain-containing protein that may function as a guanine nucleotide exchange factor that specifically activates ras-related protein Rab-10. This protein also contains a interferon stimulated response element-binding domain and may be involved in regulating the v-myc avian myelocytomatosis viral (MYC) oncogene. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 8. [provided by RefSeq, Mar 2016]
Known Variants69 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs2548461925 | 15:65,954,229 | A/G | — | uncertain significance |
| rs200193901 | 15:65,954,266 | T/C | — | uncertain significance |
| rs8027388 | 15:65,955,516 | A/G | downstream gene variant | — |
| rs374872390 | 15:65,956,925 | T/C | — | uncertain significance |
| rs2548476158 | 15:65,956,950 | T/C | — | uncertain significance |
| rs12591647 | 15:65,959,729 | T/C | intron variant | — |
| rs764650591 | 15:65,960,020 | G/A | — | uncertain significance |
| rs755938432 | 15:65,960,361 | T/C | — | uncertain significance |
| rs1360952487 | 15:65,960,394 | C/G | — | uncertain significance |
| rs765266078 | 15:65,962,261 | T/C | — | uncertain significance |
| rs763584548 | 15:65,964,135 | T/C | — | uncertain significance |
| rs564708051 | 15:65,964,155 | T/C | — | uncertain significance |
| rs1316022150 | 15:65,964,167 | G/C | — | uncertain significance |
| rs767280071 | 15:65,964,219 | G/C | — | uncertain significance |
| rs368132872 | 15:65,968,864 | A/T | — | uncertain significance |
| rs779985646 | 15:65,968,887 | T/A | — | uncertain significance |
| rs370074612 | 15:65,968,965 | C/A | — | uncertain significance |
| rs373506222 | 15:65,982,766 | G/T | — | uncertain significance |
| rs1232562335 | 15:65,982,794 | T/C | — | uncertain significance |
| rs1360122374 | 15:65,982,848 | C/T | — | uncertain significance |
| rs779608412 | 15:65,983,112 | G/A | — | uncertain significance |
| rs374306473 | 15:65,983,358 | G/A | — | uncertain significance |
| rs368064090 | 15:65,983,514 | T/C | — | uncertain significance |
| rs770699120 | 15:65,983,544 | G/A | — | likely benign |
| rs1178128642 | 15:65,983,651 | T/G | — | uncertain significance |
| rs2076963662 | 15:65,983,714 | T/A | — | uncertain significance |
| rs539198798 | 15:65,983,750 | T/C | — | uncertain significance |
| rs186696139 | 15:65,988,716 | C/T | — | uncertain significance |
| rs199610566 | 15:65,988,751 | G/A | — | uncertain significance |
| rs748829507 | 15:65,988,761 | C/T | — | uncertain significance |
| rs2548585681 | 15:65,988,803 | C/T | — | uncertain significance |
| rs2548585768 | 15:65,988,824 | C/T | — | uncertain significance |
| rs1384674790 | 15:65,992,894 | T/C | — | uncertain significance |
| rs138998131 | 15:65,993,433 | C/T | — | uncertain significance |
| rs368880135 | 15:65,994,128 | T/C | — | uncertain significance |
| rs780450925 | 15:65,994,168 | G/C | — | uncertain significance |
| rs747278346 | 15:65,994,185 | T/C | — | uncertain significance |
| rs2548614263 | 15:65,994,687 | C/T | — | uncertain significance |
| rs61754790 | 15:65,994,777 | G/A | — | uncertain significance |
| rs1165176547 | 15:65,995,346 | G/C | — | likely pathogenic |
| rs2548632007 | 15:65,998,445 | G/T | — | uncertain significance |
| rs760011499 | 15:65,998,456 | T/C | — | uncertain significance |
| rs535585248 | 15:65,998,534 | C/T | — | uncertain significance |
| rs369482205 | 15:66,007,942 | G/C | — | uncertain significance |
| rs28687655 | 15:66,007,972 | A/T | downstream gene variant | — |
| rs12900061 | 15:66,009,248 | G/A | downstream gene variant | — |
| rs1477328599 | 15:66,010,243 | C/A | — | uncertain significance |
| rs761590535 | 15:66,010,283 | T/C | — | uncertain significance |
| rs1439537819 | 15:66,021,522 | C/T | — | uncertain significance |
| rs2548757581 | 15:66,024,001 | A/G | — | uncertain significance |
| rs2548757836 | 15:66,024,029 | G/A | — | uncertain significance |
| rs11071849 | 15:66,025,010 | G/C | — | — |
| rs28574874 | 15:66,026,906 | T/G | — | — |
| rs528727634 | 15:66,030,114 | G/C | — | uncertain significance |
| rs2076176541 | 15:66,031,080 | A/C | — | uncertain significance |
| rs77559483 | 15:66,033,126 | C/A | intron variant | — |
| rs35709713 | 15:66,037,266 | A/G | intron variant | — |
| rs762245474 | 15:66,044,740 | C/T | — | uncertain significance |
| rs371225656 | 15:66,044,898 | C/T | — | uncertain significance |
| rs759592960 | 15:66,044,914 | T/G | — | uncertain significance |
| rs780824141 | 15:66,048,653 | T/C | — | uncertain significance |
| rs554243996 | 15:66,048,776 | T/C | — | uncertain significance |
| rs6494537 | 15:66,051,345 | C/T | intron variant | — |
| rs28552840 | 15:66,066,618 | G/A | — | — |
| rs28498859 | 15:66,067,777 | A/G | upstream gene variant | — |
| rs2572207 | 15:66,070,693 | C/G | — | — |
| rs2437145 | 15:66,074,028 | A/C | — | — |
| rs2414884 | 15:66,075,872 | C/G | — | — |
| rs1369313 | 15:66,084,255 | A/C | — | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.