DIXDC1

DIX domain containing 1

Summary

The protein encoded by this gene is a positive regulator of the Wnt signaling pathway. The encoded protein is found associated with gamma tubulin at the centrosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013]

Known Variants26 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs199945833	11:111,808,278	A/G	—	benign
rs587774805	11:111,815,768	C/T	—	—
rs2498095265	11:111,835,328	C/T	—	uncertain significance
rs370213735	11:111,835,336	C/G	—	uncertain significance
rs377157480	11:111,835,393	G/A	—	uncertain significance
rs782259747	11:111,839,339	G/A	—	uncertain significance
rs1859812070	11:111,839,350	A/G	—	uncertain significance
rs199891499	11:111,844,828	C/T	—	uncertain significance
rs587723931	11:111,844,843	G/A	—	uncertain significance
rs782515563	11:111,844,923	G/A	—	uncertain significance
rs930647209	11:111,845,632	C/T	—	uncertain significance
rs781863884	11:111,851,496	A/C	—	uncertain significance
rs782742979	11:111,851,499	G/A	—	uncertain significance
rs1419374563	11:111,853,087	C/T	—	likely pathogenic
rs200647738	11:111,853,096	C/T	—	uncertain significance
rs182278039	11:111,857,624	T/C	—	benign
rs373126732	11:111,859,774	A/T	missense variant	—
rs2498247218	11:111,864,220	A/C	—	uncertain significance
rs2498248903	11:111,864,434	G/T	—	uncertain significance
rs140140857	11:111,865,381	T/C	intron variant	—
rs10789855	11:111,866,015	C/T	—	—
rs587638080	11:111,873,414	C/T	—	—
rs114428192	11:111,887,482	C/A	—	uncertain significance
rs184718561	11:111,887,493	C/T	missense variant	—
rs650461	11:111,889,635	C/G	downstream gene variant	—
rs781973280	11:111,889,738	A/G	—	uncertain significance

Gene information from NCBI Gene. Variant classifications from ClinVar.