rs650461
This is a downstream gene variant variant in the DIXDC1 gene.
▶Research that mentions this SNP (1)
▶Insight in glioma susceptibility through an analysis of 6p22.3, 12p13.33-12.1, 17q22-23.2 and 18q23 SNP genotypes in familial and non-familial gliomaAssociationN=2,175Yanhong Liu et al.(2012)· Human Genetics
This family-based association study identified genetic variants associated with familial glioma by analyzing 5,122 SNPs in four chromosomal regions in 88 glioma cases with family history versus 1,100 without (discovery study) and validated findings in 84 familial and 903 sporadic cases. The strongest associations in the combined analysis were at 12p13.33-12.1 (PRMT8 rs17780102 OR=2.13, SOX5 rs7305773 OR=3.53, STYK1 rs2418087 OR=1.88) and 17q12-21.32 (SPOP rs6504618 OR=2.01, p=0.0006), with significant dose-effect relationship across four risk variants.
About DIXDC1
The protein encoded by this gene is a positive regulator of the Wnt signaling pathway. The encoded protein is found associated with gamma tubulin at the centrosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013]
View all DIXDC1 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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