DKK3
dickkopf Wnt signaling pathway inhibitor 3
Summary
This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. The expression of this gene is decreased in a variety of cancer cell lines and it may function as a tumor suppressor gene. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
Known Variants32 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs138336904 | 11:11,986,044 | G/A | — | likely benign |
| rs114429255 | 11:11,986,051 | G/A | — | uncertain significance |
| rs3206824 | 11:11,986,061 | T/C | missense variant | — |
| rs751011348 | 11:11,986,106 | C/T | — | uncertain significance |
| rs201778105 | 11:11,986,112 | G/A | — | likely pathogenic |
| rs562357604 | 11:11,986,124 | T/C | — | uncertain significance |
| rs146242862 | 11:11,986,141 | T/C | — | uncertain significance |
| rs114873269 | 11:11,986,144 | T/C | — | benign |
| rs768404301 | 11:11,986,189 | C/T | — | likely benign |
| rs532056198 | 11:11,986,204 | G/A | — | uncertain significance |
| rs373077042 | 11:11,986,216 | A/T | — | uncertain significance |
| rs2494652059 | 11:11,986,232 | G/C | — | uncertain significance |
| rs11022095 | 11:11,986,927 | A/G | intron variant | — |
| rs373832403 | 11:11,987,453 | C/T | — | uncertain significance |
| rs2291598 | 11:11,987,480 | C/T | — | uncertain significance |
| rs2494658089 | 11:11,987,488 | G/T | — | uncertain significance |
| rs371921208 | 11:11,988,527 | G/A | — | uncertain significance |
| rs199563886 | 11:11,988,563 | T/C | — | uncertain significance |
| rs201007683 | 11:11,988,570 | C/T | — | uncertain significance |
| rs371884398 | 11:11,988,636 | G/A | — | uncertain significance |
| rs7396187 | 11:11,989,151 | C/G | intron variant | — |
| rs2291599 | 11:11,989,899 | T/C | intron variant | — |
| rs1590500384 | 11:11,989,965 | G/T | — | uncertain significance |
| rs372782687 | 11:12,023,893 | G/A | — | uncertain significance |
| rs879117830 | 11:12,023,899 | G/C | — | uncertain significance |
| rs551373443 | 11:12,023,911 | T/C | — | uncertain significance |
| rs78422142 | 11:12,023,921 | T/C | — | benign |
| rs760201315 | 11:12,023,977 | G/T | — | uncertain significance |
| rs1177135659 | 11:12,030,089 | G/T | — | uncertain significance |
| rs1590566131 | 11:12,030,090 | C/T | — | uncertain significance |
| rs577841850 | 11:12,030,970 | C/T | — | — |
| rs180681722 | 11:12,033,074 | C/T | upstream gene variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.