rs3206824

This is a protein-altering variant in the DKK3 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

body height

Yengo L et al. “A saturated map of common genetic variants associated with human height.” Nature 610(7933):704-712 (2022)
Allele T
OR 0.02
p 4.0e-116
N 5,314,291
Large GWAS
European, Hispanic or Latin American, East Asian, African unspecified, South Asian
Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele T
OR 0.01
p 3.0e-19
N 394,642
Large GWAS
European
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Research that mentions this SNP (2)

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Association of 12 polymorphic variants conferring genetic risk to lung cancer in Indian population: An extensive meta‐analysis
Meta-analysisN=19,556Debmalya Sengupta et al.(2017)· Environmental and Molecular Mutagenesis

A comprehensive meta-analysis of 50 case-control studies from the Indian subcontinent identified genetic variants modifying lung cancer risk, finding FDR-corrected associations for rs3547/XRCC1 (OR=1.83-2.72) and rs1048943/CYP1A1 (OR=2.07). The rs1048943/CYP1A1 variant showed strongest associations with adenocarcinoma (OR=3.38) and squamous cell carcinoma (OR=3.53) with significant effect modification by smoking status. Global meta-analysis confirmed rs1048943/CYP1A1 association across world populations (OR=1.22, p=0.01).

Traits studied:Lung adenocarcinomaLung cancerSmall cell lung carcinomaSquamous cell carcinoma
PubMedDOIMetascience Observatory
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Type 2 diabetes susceptibility loci in the Ashkenazi Jewish population
AssociationN=1,312Michal Bronstein et al.(2008)· Human Genetics

This study characterized an Ashkenazi Jewish (AJ) population-specific genetic signature using genome-wide SNP data from 1,312 AJ individuals. Using ADMIXTURE and principal components analysis, the authors identified allelic patterns that differentiate AJ from European and Middle Eastern populations. Gene Ontology enrichment analysis of the AJ-specific genetic signature revealed enrichment in genes involved in transepithelial chloride transport (including CFTR with rs213950 showing V158M variant) and equilibrioception (PCDH15, CLRN1), implicating these pathways in the elevated prevalence of cystic fibrosis and Usher syndrome in Ashkenazi Jews. The study also identified disease-relevant alleles including MTHFR C677T (rs1801133), SH2B3 rs3184504 associated with type 1 diabetes/celiac disease, and MC1R rs1805005, and provided a validated set of 103 ancestry informative markers (AIMs) for population stratification correction.

Traits studied:Alzheimer's diseaseAncestry informative markersAshkenazi Jewish population structureAutoimmune diseasesCeliac diseaseCrohn's diseaseCystic fibrosisMelanomaMetabolic disordersMultiple sclerosisRheumatoid arthritisType 1 diabetesType 2 diabetesUsher syndrome
PubMedDOIMetascience Observatory

About DKK3

This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. The expression of this gene is decreased in a variety of cancer cell lines and it may function as a tumor suppressor gene. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

View all DKK3 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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