DOK2
docking protein 2
Summary
The protein encoded by this gene is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. This encoded protein binds p120 (RasGAP) from CML cells. [provided by RefSeq, Jul 2008]
Known Variants39 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs2486342323 | 8:21,766,878 | C/T | — | uncertain significance |
| rs2242241 | 8:21,766,881 | A/C | — | benign |
| rs1327737600 | 8:21,766,886 | G/C | — | uncertain significance |
| rs200583668 | 8:21,766,893 | C/A | — | uncertain significance |
| rs1376474759 | 8:21,766,955 | C/T | — | uncertain significance |
| rs1563297627 | 8:21,766,995 | G/A | — | uncertain significance |
| rs150641697 | 8:21,767,016 | C/T | — | uncertain significance |
| rs139826199 | 8:21,767,021 | T/C | — | uncertain significance |
| rs200790064 | 8:21,767,027 | T/C | — | uncertain significance |
| rs779421891 | 8:21,767,045 | G/C | — | uncertain significance |
| rs373240046 | 8:21,767,094 | G/C | — | uncertain significance |
| rs142966461 | 8:21,767,152 | G/C | — | uncertain significance |
| rs1809750943 | 8:21,767,193 | G/T | — | uncertain significance |
| rs569933979 | 8:21,767,225 | G/A | — | uncertain significance |
| rs779927750 | 8:21,767,231 | G/A | — | uncertain significance |
| rs746729985 | 8:21,767,237 | T/C | — | uncertain significance |
| rs570010787 | 8:21,767,243 | C/T | — | uncertain significance |
| rs368473444 | 8:21,767,244 | G/A | — | uncertain significance |
| rs1434873122 | 8:21,767,255 | C/A | — | uncertain significance |
| rs1218154387 | 8:21,767,268 | G/A | — | uncertain significance |
| rs746836815 | 8:21,767,273 | G/A | — | uncertain significance |
| rs376285375 | 8:21,767,279 | G/A | — | uncertain significance |
| rs144359058 | 8:21,767,297 | G/A | — | uncertain significance |
| rs763387364 | 8:21,767,351 | G/A | — | uncertain significance |
| rs1809770944 | 8:21,767,430 | A/C | — | uncertain significance |
| rs2486346202 | 8:21,767,435 | A/G | — | uncertain significance |
| rs756933437 | 8:21,768,191 | C/G | — | uncertain significance |
| rs377500664 | 8:21,768,284 | C/T | — | benign |
| rs371052882 | 8:21,768,299 | C/T | — | uncertain significance |
| rs1809865198 | 8:21,769,451 | A/G | — | uncertain significance |
| rs777211002 | 8:21,769,457 | G/A | — | uncertain significance |
| rs780023106 | 8:21,769,783 | T/A | — | uncertain significance |
| rs746287821 | 8:21,769,889 | G/C | — | uncertain significance |
| rs368280286 | 8:21,769,897 | C/G | — | uncertain significance |
| rs766198984 | 8:21,769,916 | G/A | — | uncertain significance |
| rs531906443 | 8:21,769,976 | C/A | — | uncertain significance |
| rs2486356654 | 8:21,770,008 | A/C | — | uncertain significance |
| rs899428 | 8:21,770,763 | T/C | intron variant | — |
| rs142660088 | 8:21,771,080 | C/A | missense variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.