DPP10
dipeptidyl peptidase like 10
Summary
This gene encodes a single-pass type II membrane protein that is a member of the S9B family in clan SC of the serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Mutations in this gene have been associated with asthma. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Known Variants76 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs186464473 | 2:115,488,312 | C/A | intron variant | — |
| rs1435879 | 2:115,492,887 | A/G | intron variant | — |
| rs6732028 | 2:115,586,939 | A/G | downstream gene variant | — |
| rs13412091 | 2:115,598,063 | T/C | upstream gene variant | — |
| rs62164492 | 2:115,798,618 | C/G | intron variant | — |
| rs192593706 | 2:115,819,000 | G/A | intron variant | — |
| rs150177043 | 2:115,893,039 | C/T | intron variant | — |
| rs771603033 | 2:115,919,527 | G/T | — | likely benign |
| rs775380081 | 2:115,919,528 | C/T | — | likely benign |
| rs149290962 | 2:115,924,941 | G/C | intron variant | — |
| rs77985378 | 2:115,932,979 | G/A | intron variant | — |
| rs193159988 | 2:116,041,073 | A/G | intron variant | — |
| rs374280028 | 2:116,066,896 | C/T | — | uncertain significance |
| rs201248540 | 2:116,101,409 | G/T | — | likely benign |
| rs201138141 | 2:116,101,417 | C/T | — | uncertain significance |
| rs150923384 | 2:116,101,420 | G/C | — | uncertain significance |
| rs577846336 | 2:116,101,476 | C/T | — | uncertain significance |
| rs138406948 | 2:116,101,477 | G/A | — | uncertain significance |
| rs143931646 | 2:116,163,808 | C/G | intron variant | — |
| rs1375144 | 2:116,241,186 | G/A | intron variant | — |
| rs144249280 | 2:116,257,106 | A/G | — | uncertain significance |
| rs141809253 | 2:116,257,109 | G/A | — | uncertain significance |
| rs138259404 | 2:116,283,497 | T/C | — | likely benign |
| rs149189485 | 2:116,431,196 | C/T | intron variant | — |
| rs777476010 | 2:116,447,278 | T/C | — | uncertain significance |
| rs1055873408 | 2:116,447,456 | G/A | — | uncertain significance |
| rs117125246 | 2:116,450,584 | C/T | intron variant | — |
| rs373242232 | 2:116,485,400 | T/G | — | uncertain significance |
| rs4308128 | 2:116,491,246 | A/C | intron variant | — |
| rs767116450 | 2:116,497,317 | G/C | — | uncertain significance |
| rs78880257 | 2:116,497,319 | A/C | — | benign |
| rs371206408 | 2:116,497,364 | A/C | — | uncertain significance |
| rs758693945 | 2:116,497,381 | T/C | — | uncertain significance |
| rs200681435 | 2:116,510,766 | A/G | — | uncertain significance |
| rs199848458 | 2:116,510,810 | A/C | — | uncertain significance |
| rs2053724 | 2:116,510,817 | G/T | missense variant | — |
| rs377189934 | 2:116,510,826 | A/G | — | uncertain significance |
| rs201296031 | 2:116,520,170 | C/T | — | uncertain significance |
| rs34741590 | 2:116,525,899 | C/T | — | benign |
| rs779793489 | 2:116,525,915 | A/T | — | uncertain significance |
| rs2472070152 | 2:116,525,940 | G/C | — | uncertain significance |
| rs1446495 | 2:116,525,960 | G/A | missense variant | — |
| rs189674147 | 2:116,526,517 | C/T | intron variant | — |
| rs761055323 | 2:116,534,803 | C/T | — | uncertain significance |
| rs150929011 | 2:116,534,805 | G/A | — | uncertain significance |
| rs762623513 | 2:116,534,809 | G/A | — | uncertain significance |
| rs1682677102 | 2:116,538,452 | C/T | — | uncertain significance |
| rs1682684998 | 2:116,538,494 | A/G | — | uncertain significance |
| rs751203156 | 2:116,538,517 | T/C | — | uncertain significance |
| rs765015688 | 2:116,538,543 | G/C | — | uncertain significance |
| rs1353563092 | 2:116,538,555 | C/G | — | uncertain significance |
| rs141057562 | 2:116,539,979 | A/G | — | benign |
| rs369287161 | 2:116,548,725 | G/C | — | uncertain significance |
| rs755729327 | 2:116,548,735 | T/C | — | uncertain significance |
| rs779129164 | 2:116,572,385 | G/A | — | uncertain significance |
| rs113462911 | 2:116,572,391 | C/T | — | benign |
| rs373895432 | 2:116,572,446 | A/G | — | uncertain significance |
| rs76210053 | 2:116,572,469 | G/A | — | benign |
| rs147125069 | 2:116,572,494 | T/G | — | benign |
| rs142359009 | 2:116,572,542 | A/G | — | likely benign |
| rs769705604 | 2:116,593,749 | T/G | — | uncertain significance |
| rs145011952 | 2:116,593,758 | T/G | — | uncertain significance |
| rs747173621 | 2:116,594,130 | A/G | — | uncertain significance |
| rs371247499 | 2:116,594,253 | G/T | — | likely benign |
| rs763684712 | 2:116,594,270 | T/A | — | uncertain significance |
| rs1259592140 | 2:116,594,276 | T/A | — | uncertain significance |
| rs2472900722 | 2:116,594,286 | G/A | — | uncertain significance |
| rs547304395 | 2:116,594,287 | A/G | — | uncertain significance |
| rs2472901214 | 2:116,594,301 | A/G | — | uncertain significance |
| rs2472901402 | 2:116,594,313 | A/G | — | uncertain significance |
| rs770338875 | 2:116,594,316 | G/T | — | uncertain significance |
| rs369937567 | 2:116,598,326 | C/A | — | uncertain significance |
| rs146482002 | 2:116,598,397 | C/A | — | likely benign |
| rs140053981 | 2:116,599,787 | G/A | — | uncertain significance |
| rs775542778 | 2:116,599,844 | A/G | — | uncertain significance |
| rs144407365 | 2:116,599,847 | A/G | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.