rs1375144
This is a intron variant variant in the DPP10 gene.
▶Research that mentions this SNP (1)
▶Propensity score‐based nonparametric test revealing genetic variants underlying bipolar disorderMethodsN=5,002Yuan Jiang et al.(2011)· Genetic Epidemiology
This methods paper presents a propensity score-based nonparametric test for genetic association that adjusts for covariates using genomic propensity scores. Applied to 1,998 bipolar disorder cases and 3,004 controls from the Wellcome Trust Case Control Consortium, the method identified three SNPs on chromosome 16 (rs2387823, rs1344485, rs11647459; p < 5×10⁻⁷) in strong linkage disequilibrium near RPGRIP1L that were missed by standard unadjusted methods, demonstrating that covariate-adjusted approaches can reveal genetic variants underlying bipolar disorder.
About DPP10
This gene encodes a single-pass type II membrane protein that is a member of the S9B family in clan SC of the serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Mutations in this gene have been associated with asthma. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
View all DPP10 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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