DTL

denticleless E3 ubiquitin protein ligase adapter

Summary

Contributes to ubiquitin-protein transferase activity. Involved in several processes, including protein ubiquitination; regulation of G2/M transition of mitotic cell cycle; and translesion synthesis. Located in centrosome; cytosol; and nuclear lumen. Part of Cul4A-RING E3 ubiquitin ligase complex and Cul4B-RING E3 ubiquitin ligase complex. [provided by Alliance of Genome Resources, Jul 2025]

Known Variants32 total

rsidPosition (GRCh37)AllelesClassClinVar
rs1414515211:212,209,243A/Guncertain significance
rs15789921:212,211,174G/Tupstream gene variant
rs1440208121:212,216,369G/Alikely benign
rs10001556891:212,216,386G/Cuncertain significance
rs24646184141:212,216,457T/Auncertain significance
rs5297174441:212,218,094T/Glikely benign
rs7569695741:212,220,516G/Auncertain significance
rs108639361:212,237,798G/Aintron variant
rs24646992161:212,238,338G/Cuncertain significance
rs1896449221:212,238,361C/Tuncertain significance
rs75409681:212,239,485T/Cintron variant
rs7783174941:212,240,197A/Tuncertain significance
rs7643804201:212,241,971G/Auncertain significance
rs5619861011:212,242,016T/Auncertain significance
rs111198401:212,246,168C/Tupstream gene variant
rs7463469131:212,251,570C/Tuncertain significance
rs16548907421:212,251,581T/Cuncertain significance
rs1411320681:212,254,046G/Alikely benign
rs108639371:212,259,964A/T
rs16555817571:212,273,725C/Tuncertain significance
rs3710322421:212,273,739T/Guncertain significance
rs16555827711:212,273,753C/Guncertain significance
rs24648251371:212,273,829G/Auncertain significance
rs7487131881:212,273,884C/Tuncertain significance
rs1464817511:212,273,891C/Tuncertain significance
rs12062279021:212,273,897C/Tuncertain significance
rs7489725481:212,274,113A/Guncertain significance
rs3684332751:212,274,340C/Tuncertain significance
rs5576425301:212,274,425C/Tuncertain significance
rs1146717871:212,276,234A/Gbenign
rs24648358241:212,276,251T/Alikely benign
rs112753001:212,277,589C/A

Gene information from NCBI Gene. Variant classifications from ClinVar.