DUOX2

dual oxidase 2

Summary

The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes this encoded protein and DUOX1. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. [provided by RefSeq, Jul 2008]

Known Variants1,567 total

rsidPosition (GRCh37)AllelesClassClinVar
rs36890102115:45,384,910C/T—uncertain significance
rs57540540115:45,384,911G/A—uncertain significance
rs77091717415:45,384,920C/T—uncertain significance
rs88605118615:45,384,991T/C—uncertain significance
rs90302502115:45,384,996C/T—uncertain significance
rs88605118715:45,385,033T/G—uncertain significance
rs88605118815:45,385,104A/T—uncertain significance
rs88605118915:45,385,118G/A—uncertain significance
rs55165400815:45,385,145G/A—uncertain significance
rs19199751015:45,385,203G/A—uncertain significance
rs11734131415:45,385,284C/T—uncertain significance
rs13790952515:45,385,434C/A—uncertain significance
rs56694604115:45,385,491C/T—uncertain significance
rs477574415:45,385,496A/T—benign
rs37004878515:45,385,570G/T—uncertain significance
rs148586926515:45,385,583G/A—uncertain significance
rs802492215:45,385,626T/C—benign
rs374322115:45,385,683C/T—uncertain significance
rs14337642215:45,385,724G/A—uncertain significance
rs1107044115:45,385,757G/A—likely benign
rs189381424415:45,385,763T/C—uncertain significance
rs1232404415:45,385,870C/T—benign
rs56153228415:45,385,873C/T—uncertain significance
rs374322215:45,385,895A/G—benign
rs1085142015:45,385,916C/T—benign
rs18353533815:45,385,930A/G—uncertain significance
rs76633838515:45,385,931T/C—uncertain significance
rs189381922015:45,385,943A/C—uncertain significance
rs101110814215:45,385,995C/T—uncertain significance
rs189382136815:45,386,004T/C—uncertain significance
rs75494541615:45,386,121G/A—uncertain significance
rs189382855915:45,386,276A/C—uncertain significance
rs7516371515:45,386,311G/A—benign
rs250473493015:45,386,351G/A—likely benign
rs189383121615:45,386,357C/T—likely benign
rs20122919315:45,386,358T/C—conflicting classifications of pathogenicity
rs76363925115:45,386,361T/C—uncertain significance
rs75434249615:45,386,364T/C—uncertain significance
rs147256932215:45,386,366G/A—likely benign
rs100930898915:45,386,367T/C—uncertain significance
rs77080392815:45,386,369C/A—likely benign
rs37297531115:45,386,370A/G—uncertain significance
rs174963562015:45,386,372G/A—likely benign
rs75080277415:45,386,376T/G—uncertain significance
rs189383463515:45,386,379G/C—uncertain significance
rs78030946715:45,386,383G/A—uncertain significance
rs214113852615:45,386,391C/T—uncertain significance
rs20038288915:45,386,392T/G—likely benign
rs74812796415:45,386,397A/G—likely benign
rs74878976015:45,386,398C/G—uncertain significance
rs156697042615:45,386,399G/A—likely benign
rs102493023015:45,386,406C/T—uncertain significance
rs137415163715:45,386,410C/T—uncertain significance
rs214113858115:45,386,411C/T—likely benign
rs77198200915:45,386,414C/A—uncertain significance
rs14587750215:45,386,420A/G—likely benign
rs76037443715:45,386,423C/A—uncertain significance
rs77623236315:45,386,426G/A—likely benign
rs76578125515:45,386,434C/A—uncertain significance
rs189383740315:45,386,437G/C—uncertain significance
rs250473520315:45,386,438A/G—likely benign
rs75880982915:45,386,439G/C—uncertain significance
rs250473521915:45,386,442C/T—likely pathogenic
rs36851241215:45,386,443C/T—pathogenic
rs20179328415:45,386,444G/A—likely benign
rs214113862415:45,386,449T/C—uncertain significance
rs250473526915:45,386,451A/C—uncertain significance
rs75524998915:45,386,452A/G—uncertain significance
rs214113863215:45,386,453C/A—likely benign
rs74826214015:45,386,458C/T—uncertain significance
rs37116776615:45,386,459G/A—likely benign
rs137716536715:45,386,462C/A—uncertain significance
rs77905291815:45,386,466C/T—likely benign
rs14779109715:45,386,467G/C—uncertain significance
rs87911286315:45,386,478G/A—likely benign
rs77203322815:45,386,486A/G—likely benign
rs189384010115:45,386,488A/C—likely benign
rs717136615:45,386,656T/G—benign
rs76784539315:45,386,754G/A—likely benign
rs214113896415:45,386,763G/A—pathogenic
rs138813294815:45,386,769G/A—uncertain significance
rs77156208015:45,386,773C/T—likely benign
rs189385019515:45,386,775C/T—uncertain significance
rs55600883515:45,386,800G/A—likely benign
rs214113898815:45,386,802A/G—uncertain significance
rs122842742215:45,386,803G/A—likely benign
rs57604171815:45,386,804G/T—uncertain significance
rs5632314615:45,386,806G/A—likely benign
rs76833449415:45,386,807G/A—uncertain significance
rs189385140215:45,386,809A/T—likely benign
rs14454342015:45,386,810C/T—uncertain significance
rs74772095215:45,386,811G/A—uncertain significance
rs141026066015:45,386,818G/C—uncertain significance
rs250473632815:45,386,821G/T—likely benign
rs77272743315:45,386,822G/A—uncertain significance
rs250473634515:45,386,823T/A—uncertain significance
rs250473635315:45,386,824G/A—likely benign
rs89856129115:45,386,831C/T—uncertain significance
rs36800469515:45,386,832G/A—uncertain significance
rs77143263515:45,386,833C/G—likely benign

Showing 100 of 1,567 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.