DUSP1
dual specificity phosphatase 1
Summary
The protein encoded by this gene is a phosphatase with dual specificity for tyrosine and threonine. The encoded protein can dephosphorylate MAP kinase MAPK1/ERK2, which results in its involvement in several cellular processes. This protein appears to play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation. Finally, the encoded protein can make some solid tumors resistant to both chemotherapy and radiotherapy, making it a target for cancer therapy. [provided by RefSeq, Aug 2017]
Known Variants23 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs322351 | 5:172,194,873 | C/T | regulatory region variant | — |
| rs151014356 | 5:172,195,782 | T/C | — | uncertain significance |
| rs1312360293 | 5:172,195,857 | C/A | — | uncertain significance |
| rs778085088 | 5:172,195,916 | G/C | — | uncertain significance |
| rs2480175868 | 5:172,195,919 | C/A | — | uncertain significance |
| rs149572166 | 5:172,196,014 | A/G | — | likely benign |
| rs772577199 | 5:172,196,124 | T/C | — | uncertain significance |
| rs1047333158 | 5:172,196,133 | A/C | — | uncertain significance |
| rs1292142870 | 5:172,196,649 | T/C | — | uncertain significance |
| rs1255249281 | 5:172,196,707 | C/T | — | uncertain significance |
| rs372702653 | 5:172,196,722 | C/T | — | uncertain significance |
| rs34471628 | 5:172,196,752 | A/G | missense variant | — |
| rs375131922 | 5:172,197,204 | T/C | — | uncertain significance |
| rs2480178441 | 5:172,197,223 | T/C | — | uncertain significance |
| rs34507926 | 5:172,197,581 | G/C | splice region variant | — |
| rs759155703 | 5:172,197,614 | G/C | — | likely benign |
| rs923998270 | 5:172,197,631 | G/A | — | uncertain significance |
| rs1430996279 | 5:172,197,681 | G/T | — | uncertain significance |
| rs1256637984 | 5:172,197,777 | A/G | — | uncertain significance |
| rs1268245159 | 5:172,197,781 | C/A | — | uncertain significance |
| rs34013988 | 5:172,197,790 | C/T | missense variant | — |
| rs881152 | 5:172,198,555 | G/C | — | — |
| rs34683389 | 5:172,198,639 | C/A | regulatory region variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.