EIF3A
eukaryotic translation initiation factor 3 subunit A
Summary
Enables RNA binding activity. Contributes to translation initiation factor activity. Involved in IRES-dependent viral translational initiation; formation of cytoplasmic translation initiation complex; and viral translational termination-reinitiation. Located in cytosol; nucleolus; and nucleoplasm. Part of eukaryotic translation initiation factor 3 complex. [provided by Alliance of Genome Resources, Jul 2025]
Known Variants77 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs751564493 | 10:120,795,601 | G/A | — | uncertain significance |
| rs143903271 | 10:120,795,603 | C/T | — | uncertain significance |
| rs754701550 | 10:120,795,609 | G/A | — | uncertain significance |
| rs61729181 | 10:120,795,626 | A/T | — | benign |
| rs915716740 | 10:120,795,640 | C/A | — | uncertain significance |
| rs775695722 | 10:120,795,666 | C/T | — | uncertain significance |
| rs1198258688 | 10:120,795,672 | C/T | — | uncertain significance |
| rs771120379 | 10:120,796,646 | A/G | — | uncertain significance |
| rs768599574 | 10:120,796,676 | C/T | — | uncertain significance |
| rs774454537 | 10:120,796,677 | G/T | — | uncertain significance |
| rs139392109 | 10:120,796,703 | G/C | — | uncertain significance |
| rs556140038 | 10:120,796,720 | C/T | — | uncertain significance |
| rs938443375 | 10:120,796,759 | C/T | — | uncertain significance |
| rs61729183 | 10:120,796,766 | A/C | — | uncertain significance |
| rs1848145702 | 10:120,796,787 | C/G | — | uncertain significance |
| rs2493592414 | 10:120,797,765 | C/T | — | uncertain significance |
| rs62636533 | 10:120,797,799 | T/G | — | benign |
| rs1848164509 | 10:120,797,876 | C/T | — | uncertain significance |
| rs773874233 | 10:120,797,877 | G/A | — | uncertain significance |
| rs2493592672 | 10:120,797,919 | C/T | — | uncertain significance |
| rs10787899 | 10:120,798,655 | G/C | — | — |
| rs373036457 | 10:120,801,520 | G/A | — | uncertain significance |
| rs2493597255 | 10:120,801,544 | T/C | — | uncertain significance |
| rs202128409 | 10:120,801,593 | G/A | — | uncertain significance |
| rs2493597518 | 10:120,801,654 | G/C | — | uncertain significance |
| rs2493597546 | 10:120,801,661 | T/C | — | uncertain significance |
| rs781737428 | 10:120,801,663 | G/A | — | likely benign |
| rs201878122 | 10:120,801,743 | G/A | — | uncertain significance |
| rs2493597711 | 10:120,801,753 | C/G | — | uncertain significance |
| rs199981646 | 10:120,801,760 | C/T | — | uncertain significance |
| rs756616657 | 10:120,801,769 | C/A | — | uncertain significance |
| rs2493597783 | 10:120,801,776 | C/G | — | uncertain significance |
| rs564332910 | 10:120,801,783 | C/T | — | uncertain significance |
| rs777884334 | 10:120,801,827 | G/A | — | uncertain significance |
| rs762770253 | 10:120,801,833 | G/A | — | uncertain significance |
| rs141022993 | 10:120,801,896 | G/A | — | likely benign |
| rs113389368 | 10:120,801,908 | T/A | — | benign |
| rs765798154 | 10:120,801,964 | T/C | — | uncertain significance |
| rs550694488 | 10:120,802,004 | G/A | — | uncertain significance |
| rs200447155 | 10:120,802,009 | T/C | — | likely benign |
| rs532138 | 10:120,802,053 | A/T | — | benign |
| rs376222097 | 10:120,802,101 | G/C | — | uncertain significance |
| rs748028122 | 10:120,802,115 | C/G | — | uncertain significance |
| rs2493598633 | 10:120,802,127 | T/C | — | uncertain significance |
| rs372977820 | 10:120,802,157 | G/A | — | likely benign |
| rs761041318 | 10:120,802,172 | C/T | — | uncertain significance |
| rs369943865 | 10:120,802,252 | T/C | — | uncertain significance |
| rs658352 | 10:120,803,788 | T/C | intron variant | — |
| rs2493608365 | 10:120,809,451 | C/G | — | uncertain significance |
| rs776444945 | 10:120,809,479 | C/T | — | uncertain significance |
| rs762663906 | 10:120,809,495 | G/A | — | uncertain significance |
| rs61729195 | 10:120,810,091 | T/C | — | benign |
| rs77382849 | 10:120,810,098 | C/T | — | benign |
| rs145288541 | 10:120,810,177 | T/G | missense variant | — |
| rs1368724391 | 10:120,810,742 | C/T | — | uncertain significance |
| rs138627360 | 10:120,810,808 | T/G | — | uncertain significance |
| rs1564754055 | 10:120,816,358 | T/C | — | uncertain significance |
| rs766470835 | 10:120,816,365 | T/C | — | uncertain significance |
| rs757829140 | 10:120,817,746 | G/A | — | uncertain significance |
| rs770069171 | 10:120,819,152 | G/A | — | uncertain significance |
| rs1230125116 | 10:120,819,199 | G/C | — | uncertain significance |
| rs755496726 | 10:120,820,345 | C/G | — | uncertain significance |
| rs149409844 | 10:120,820,747 | G/T | — | likely benign |
| rs144766795 | 10:120,820,799 | T/C | — | benign |
| rs146844229 | 10:120,820,826 | T/C | — | likely benign |
| rs1843957301 | 10:120,824,975 | C/T | — | uncertain significance |
| rs751057698 | 10:120,830,444 | G/C | — | uncertain significance |
| rs1490846075 | 10:120,830,483 | T/C | — | uncertain significance |
| rs141344937 | 10:120,830,487 | T/C | — | uncertain significance |
| rs760766102 | 10:120,830,597 | G/C | — | uncertain significance |
| rs942122392 | 10:120,832,428 | C/T | — | uncertain significance |
| rs2493642880 | 10:120,832,435 | C/T | — | uncertain significance |
| rs143854254 | 10:120,832,573 | G/C | — | benign |
| rs375386657 | 10:120,833,262 | T/C | — | likely benign |
| rs1409729202 | 10:120,833,280 | C/T | — | likely benign |
| rs758355282 | 10:120,840,181 | G/A | — | uncertain significance |
| rs3824830 | 10:120,840,661 | A/G | regulatory region variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.