Trait
SNPs associated with Keratoconus
58 genetic variants across 18 genes have been associated with Keratoconus in published research. Key genes include COL12A1, COL1A1, COL6A1.
Associated variants58 total
| rsid | Gene | Effect | Evidence |
|---|---|---|---|
| rs375290574 | — | GWAS association (p=2.0e-16) | Major Consortium Study |
| rs544696584 | — | GWAS association (p=1.0e-14) | Major Consortium Study |
| rs188993616 | MRPS35 | GWAS association (p=9.0e-14) | Major Consortium Study |
| rs962307678 | — | GWAS association (p=5.0e-13) | Major Consortium Study |
| rs192984922 | — | GWAS association (p=1.0e-12) | Major Consortium Study |
| rs144619021 | — | GWAS association (p=2.0e-12) | Major Consortium Study |
| rs574177860 | SPRY4-AS1 | GWAS association (p=3.0e-12) | Major Consortium Study |
| rs575273090 | — | GWAS association (p=4.0e-12) | Major Consortium Study |
| rs567010138 | PSD3 | GWAS association (p=4.0e-12) | Major Consortium Study |
| rs181856846 | — | GWAS association (p=4.0e-12) | Major Consortium Study |
| rs373192492 | — | GWAS association (p=5.0e-12) | Major Consortium Study |
| rs183801341 | LINC01876 | GWAS association (p=6.0e-12) | Major Consortium Study |
| rs532547695 | — | GWAS association (p=6.0e-12) | Major Consortium Study |
| rs374478814 | LOC105374894 | GWAS association (p=1.0e-11) | Major Consortium Study |
| rs943423 | — | GWAS association (p=1.0e-11) | Major Consortium Study |
| rs549382303 | — | GWAS association (p=1.0e-11) | Major Consortium Study |
| rs914678483 | — | GWAS association (p=1.0e-11) | Major Consortium Study |
| rs552411949 | SH2D6 | GWAS association (p=2.0e-11) | Major Consortium Study |
| rs185418622 | LOC105375282 | GWAS association (p=2.0e-11) | Major Consortium Study |
| rs117202086 | LOC105369496 | GWAS association (p=2.0e-11) | Major Consortium Study |
| rs574037063 | — | GWAS association (p=2.0e-11) | Major Consortium Study |
| rs182443557 | MCTP1 | GWAS association (p=3.0e-11) | Major Consortium Study |
| rs2721051 | — | GWAS association (p=6.0e-35) | Large GWAS |
| rs3118518 | — | GWAS association (p=2.0e-28) | Large GWAS |
| rs4894414 | — | GWAS association (p=1.0e-26) | Large GWAS |
| rs7117921 | PIDD1 | GWAS association (p=1.0e-26) | Large GWAS |
| rs12912010 | — | GWAS association (p=2.0e-26) | Large GWAS |
| rs35523808 | COL12A1 | GWAS association (p=3.0e-25) | Large GWAS |
| rs840464 | — | GWAS association (p=2.0e-20) | Large GWAS |
| rs11117401 | ZNF469 | GWAS association (p=4.0e-20) | Large GWAS |
| rs1324175 | — | GWAS association (p=3.0e-19) | Large GWAS |
| rs12515400 | — | GWAS association (p=3.0e-18) | Large GWAS |
| rs12603055 | KIF1C | GWAS association (p=2.0e-14) | Large GWAS |
| rs17285550 | — | GWAS association (p=3.0e-12) | Large GWAS |
| rs2143683 | — | GWAS association (p=4.0e-12) | Large GWAS |
| rs658352 | EIF3A | GWAS association (p=4.0e-12) | Large GWAS |
| rs76747345 | — | GWAS association (p=7.0e-12) | Large GWAS |
| rs4646785 | — | GWAS association (p=9.0e-12) | Large GWAS |
| rs142493024 | COL6A1 | GWAS association (p=9.0e-12) | Large GWAS |
| rs11145948 | — | GWAS association (p=1.0e-11) | Large GWAS |
| rs6106210 | — | GWAS association (p=3.0e-11) | Large GWAS |
| rs2417930 | — | GWAS association (p=3.0e-11) | Large GWAS |
| rs6904450 | — | GWAS association (p=6.0e-11) | Large GWAS |
| rs56161228 | MIR193A | GWAS association (p=3.0e-10) | Large GWAS |
| rs1453379 | — | GWAS association (p=3.0e-10) | Large GWAS |
| rs1200108 | — | GWAS association (p=5.0e-10) | Large GWAS |
| rs116792882 | — | GWAS association (p=5.0e-10) | Large GWAS |
| rs3782473 | — | GWAS association (p=7.0e-10) | Large GWAS |
| rs11634895 | — | GWAS association (p=8.0e-10) | Large GWAS |
| rs11021221 | — | GWAS association (p=1.0e-09) | Large GWAS |
| rs17340879 | — | GWAS association (p=2.0e-09) | Large GWAS |
| rs2075556 | COL1A1 | GWAS association (p=3.0e-09) | Large GWAS |
| rs6669560 | — | GWAS association (p=3.0e-09) | Large GWAS |
| rs756878 | — | GWAS association (p=4.0e-09) | Large GWAS |
| rs12948086 | SKAP1 | GWAS association (p=5.0e-09) | Large GWAS |
| rs761276 | — | GWAS association (p=8.0e-09) | Large GWAS |
| rs117905623 | — | GWAS association (p=2.0e-08) | Large GWAS |
| rs76194223 | — | GWAS association (p=2.0e-08) | Large GWAS |
Associations aggregated from the GWAS Catalog and curated literature. Informational only — not medical advice.