FAAH2
fatty acid amide hydrolase 2
Summary
This gene encodes a fatty acid amide hydrolase that shares a conserved protein motif with the amidase signature family of enzymes. The encoded enzyme is able to catalyze the hydrolysis of a broad range of bioactive lipids, including those from the three main classes of fatty acid amides; N-acylethanolamines, fatty acid primary amides and N-acyl amino acids. This enzyme has a preference for monounsaturated acyl chains as a substrate. Alternate splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2017]
Known Variants71 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs516333 | X:57,196,892 | G/A | intergenic variant | — |
| rs72621725 | X:57,260,780 | G/C | — | — |
| rs2213509 | X:57,294,767 | A/T | — | — |
| rs139470886 | X:57,309,130 | G/T | — | — |
| rs2516023 | X:57,313,357 | T/C | — | benign |
| rs146874627 | X:57,313,382 | C/T | — | benign |
| rs2051826047 | X:57,313,385 | C/T | — | uncertain significance |
| rs553116233 | X:57,313,403 | C/T | — | uncertain significance |
| rs780846459 | X:57,313,416 | G/T | — | uncertain significance |
| rs769942516 | X:57,318,953 | A/C | — | conflicting classifications of pathogenicity |
| rs866870044 | X:57,318,978 | C/T | — | likely benign |
| rs762458246 | X:57,318,991 | A/G | — | uncertain significance |
| rs767149894 | X:57,319,016 | G/A | — | likely benign |
| rs7058676 | X:57,348,523 | C/T | intron variant | — |
| rs2519914571 | X:57,358,052 | T/A | — | uncertain significance |
| rs1569266807 | X:57,358,054 | A/G | — | uncertain significance |
| rs2053408392 | X:57,358,057 | A/C | — | uncertain significance |
| rs184337210 | X:57,358,063 | C/T | — | likely benign |
| rs773977954 | X:57,358,064 | G/A | — | uncertain significance |
| rs747426561 | X:57,358,099 | G/A | — | uncertain significance |
| rs781669402 | X:57,358,110 | G/A | — | likely benign |
| rs1222691508 | X:57,358,184 | T/C | — | uncertain significance |
| rs201024763 | X:57,358,193 | G/A | — | conflicting classifications of pathogenicity |
| rs186994377 | X:57,358,203 | C/T | — | likely benign |
| rs2519918104 | X:57,358,207 | T/C | — | uncertain significance |
| rs777298575 | X:57,367,734 | G/A | — | uncertain significance |
| rs774654577 | X:57,367,791 | T/C | — | uncertain significance |
| rs935963549 | X:57,367,806 | G/C | — | uncertain significance |
| rs2053683157 | X:57,367,828 | T/A | — | uncertain significance |
| rs1560514 | X:57,386,648 | A/G | intron variant | — |
| rs765703450 | X:57,405,084 | G/T | — | uncertain significance |
| rs776131446 | X:57,405,086 | G/A | — | uncertain significance |
| rs368527435 | X:57,405,122 | G/C | — | conflicting classifications of pathogenicity |
| rs765948487 | X:57,405,125 | G/C | — | uncertain significance |
| rs778728366 | X:57,405,131 | G/T | — | not provided |
| rs4826543 | X:57,405,163 | T/C | — | benign |
| rs148907702 | X:57,405,179 | G/T | — | uncertain significance |
| rs202011260 | X:57,405,218 | A/C | — | likely benign |
| rs1351914209 | X:57,407,392 | G/A | — | uncertain significance |
| rs766389808 | X:57,407,396 | G/A | — | uncertain significance |
| rs200177220 | X:57,407,400 | C/A | — | uncertain significance |
| rs199898402 | X:57,407,456 | G/T | — | uncertain significance |
| rs5960969 | X:57,426,371 | G/T | — | — |
| rs12688558 | X:57,448,902 | T/G | intron variant | — |
| rs184042641 | X:57,458,378 | G/A | — | uncertain significance |
| rs145812437 | X:57,458,413 | G/A | — | uncertain significance |
| rs974561506 | X:57,458,428 | G/T | — | uncertain significance |
| rs138462668 | X:57,458,438 | G/A | — | likely benign |
| rs377460431 | X:57,458,442 | T/C | — | uncertain significance |
| rs28827315 | X:57,464,651 | T/G | — | — |
| rs370664625 | X:57,473,384 | G/T | — | uncertain significance |
| rs1333565102 | X:57,473,419 | G/A | — | pathogenic |
| rs2521812161 | X:57,473,455 | A/G | — | uncertain significance |
| rs889656740 | X:57,473,470 | T/C | — | uncertain significance |
| rs1821118 | X:57,474,943 | A/T | — | benign |
| rs748317673 | X:57,474,979 | G/T | — | uncertain significance |
| rs199790210 | X:57,474,990 | G/A | — | likely benign |
| rs144419744 | X:57,475,022 | G/T | — | likely benign |
| rs760161926 | X:57,475,035 | G/A | — | uncertain significance |
| rs200875647 | X:57,475,061 | G/T | — | uncertain significance |
| rs1298456293 | X:57,475,088 | C/T | — | uncertain significance |
| rs147173444 | X:57,475,100 | G/T | — | uncertain significance |
| rs760074041 | X:57,475,107 | A/C | — | uncertain significance |
| rs375354837 | X:57,475,126 | A/T | — | likely benign |
| rs1367830 | X:57,475,132 | T/C | — | benign |
| rs1449740639 | X:57,515,228 | C/T | — | uncertain significance |
| rs139175109 | X:57,515,249 | G/A | — | likely benign |
| rs746153651 | X:57,515,250 | G/A | — | uncertain significance |
| rs377395090 | X:57,515,286 | T/G | — | likely benign |
| rs1240912829 | X:57,515,336 | G/C | — | uncertain significance |
| rs762805177 | X:57,515,354 | G/C | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.