FAT1

FAT atypical cadherin 1

Summary

This gene is an ortholog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has five epidermal growth factor (EGF)-like repeats and one laminin A-G domain. This gene is expressed at high levels in a number of fetal epithelia. Its product probably functions as an adhesion molecule and/or signaling receptor, and is likely to be important in developmental processes and cell communication. Transcript variants derived from alternative splicing and/or alternative promoter usage exist, but they have not been fully described. [provided by RefSeq, Jul 2008]

Known Variants1,133 total

rsidPosition (GRCh37)AllelesClassClinVar
rs76809374:187,509,492C/T—benign
rs738736434:187,509,604G/A—likely benign
rs755468284:187,509,614G/A—benign
rs13811755784:187,509,739T/C—likely benign
rs3735155474:187,509,755C/G—likely benign
rs1420574014:187,509,786G/A—likely benign
rs3760021944:187,509,791C/T—likely benign
rs24772187054:187,509,816C/T—uncertain significance
rs1463284574:187,509,838C/T—uncertain significance
rs3714598684:187,509,841C/T—uncertain significance
rs11792538934:187,509,854G/A—likely benign
rs7568287694:187,509,856A/G—uncertain significance
rs1484680164:187,509,861G/C—likely benign
rs3714519144:187,509,868C/T—uncertain significance
rs7699645614:187,509,883C/T—uncertain significance
rs24772201534:187,509,886T/C—uncertain significance
rs7734282594:187,509,893G/A—likely benign
rs2009394224:187,509,906G/C—uncertain significance
rs13945467904:187,509,919C/T—uncertain significance
rs1426123294:187,509,923G/A—benign
rs5559317554:187,509,927G/A—likely benign
rs1926091674:187,509,931C/T—likely benign
rs21263507534:187,509,976T/C—uncertain significance
rs2014775484:187,510,008T/C—uncertain significance
rs1837289324:187,510,024C/T—uncertain significance
rs1509736814:187,510,025G/A—benign
rs7720545944:187,510,029G/A—uncertain significance
rs1999277854:187,510,037A/C—uncertain significance
rs1893432664:187,510,038T/C—uncertain significance
rs14159435134:187,510,039T/G—uncertain significance
rs1396238584:187,510,049C/T—likely benign
rs354851764:187,510,072G/A—likely benign
rs3754250154:187,510,101G/A—conflicting classifications of pathogenicity
rs3686666714:187,510,102C/T—uncertain significance
rs3748169944:187,510,114C/T—uncertain significance
rs1477764004:187,510,154G/A—likely benign
rs7590738974:187,510,160T/G—uncertain significance
rs5648579434:187,510,162A/G—likely benign
rs3753243764:187,510,199G/A—likely benign
rs5700071064:187,510,237G/A—uncertain significance
rs14092565734:187,510,248G/A—uncertain significance
rs2018477594:187,510,258C/T—uncertain significance
rs37753074:187,510,280G/A—benign
rs3723553494:187,510,296A/G—uncertain significance
rs7587573644:187,510,305T/C—uncertain significance
rs7783754614:187,510,308T/G—uncertain significance
rs341745914:187,510,319C/T—benign
rs5353172184:187,510,324T/C—uncertain significance
rs5584594094:187,510,329G/A—uncertain significance
rs1929100044:187,510,339C/T—conflicting classifications of pathogenicity
rs3699942234:187,510,341C/G—uncertain significance
rs7746857344:187,510,342T/C—uncertain significance
rs2016189364:187,510,355T/G—likely benign
rs7526794834:187,510,357A/G—uncertain significance
rs1145946304:187,510,557C/G—likely benign
rs1157118504:187,516,525G/A—benign
rs23069874:187,516,655T/Aintron variantbenign
rs794039024:187,516,705T/C—likely benign
rs753064824:187,516,770G/A—likely benign
rs1433154164:187,516,776G/A—likely benign
rs48627214:187,516,814T/C—likely benign
rs3712073204:187,516,840C/A—likely benign
rs7456839524:187,516,850A/G—likely benign
rs8678333434:187,516,853G/A—likely benign
rs7618720724:187,516,856C/T—likely benign
rs11909118584:187,516,878A/G—uncertain significance
rs12988654:187,516,880A/G—benign
rs3703461774:187,516,907G/A—likely benign
rs3750735154:187,516,927G/A—uncertain significance
rs801208464:187,516,939G/T—likely benign
rs5462551524:187,516,943C/T—likely benign
rs13622544544:187,516,989A/C—likely benign
rs3742550404:187,516,994T/C—likely benign
rs1147477294:187,517,210C/T—benign
rs3759702864:187,517,699T/C—uncertain significance
rs21263866424:187,517,736T/G—uncertain significance
rs7495394384:187,517,757G/C—uncertain significance
rs38220604:187,517,758G/A—benign
rs3777026554:187,517,762G/T—uncertain significance
rs5545369094:187,517,785G/A—likely benign
rs1824689054:187,517,794C/T—likely benign
rs13981332344:187,517,814C/T—uncertain significance
rs7672525194:187,517,826C/T—uncertain significance
rs7540680904:187,517,827G/A—likely benign
rs7504589754:187,517,839G/A—likely benign
rs13888804804:187,517,848G/A—likely benign
rs9508801424:187,517,853G/C—uncertain significance
rs9835241694:187,517,874C/A—likely pathogenic
rs3736896244:187,517,886G/A—conflicting classifications of pathogenicity
rs7522362214:187,517,893A/C—uncertain significance
rs3704652674:187,517,920C/T—likely benign
rs7523933984:187,517,947C/G—likely benign
rs3682676964:187,518,002G/A—uncertain significance
rs7517166204:187,518,019C/T—likely benign
rs7484060984:187,518,023G/C—uncertain significance
rs1474051004:187,518,024C/T—likely benign
rs727162444:187,518,041C/T—likely benign
rs7516268164:187,518,071C/T—uncertain significance
rs2019607634:187,518,072G/A—uncertain significance
rs7678993234:187,518,087G/C—uncertain significance

Showing 100 of 1,133 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.