FBXL20

F-box and leucine rich repeat protein 20

Summary

Members of the F-box protein family, such as FBXL20, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

Known Variants35 total

rsidPosition (GRCh37)AllelesClassClinVar
rs374434917:37,414,842C/Tdownstream gene variant
rs1107889617:37,415,544C/Tdownstream gene variant
rs75484021217:37,420,483C/Tuncertain significance
rs14752012217:37,420,492C/Tuncertain significance
rs14550384017:37,421,655C/Tuncertain significance
rs77630130517:37,431,322C/Auncertain significance
rs7282339317:37,433,486T/Gintron variant
rs80142917:37,435,378T/Cintron variant
rs124875629117:37,437,681G/Cuncertain significance
rs75070067217:37,437,692T/Cuncertain significance
rs53262162417:37,438,986G/Auncertain significance
rs14347405817:37,439,081C/Auncertain significance
rs61219417:37,442,707T/Aintron variant
rs68394817:37,447,448T/Cintron variant
rs57508637717:37,455,252T/Cuncertain significance
rs36914670917:37,455,333C/Tuncertain significance
rs80141717:37,458,872C/Tintron variant
rs64918017:37,464,959A/Cintron variant
rs80141917:37,466,327A/Gintron variant
rs974734217:37,474,196C/Tintron variant
rs807229717:37,478,048A/C
rs1022122317:37,489,100T/A
rs14678198117:37,493,598C/Aintron variant
rs37183611917:37,499,434G/Auncertain significance
rs991630217:37,499,949T/Cintron variant
rs989450017:37,515,735G/Cregulatory region variant
rs650350617:37,524,653C/Aintron variant
rs11341451217:37,535,298C/Tintron variant
rs7329305117:37,535,336T/G
rs989906917:37,540,772A/Gintron variant
rs720848717:37,543,449T/A
rs989267517:37,549,200C/G
rs11382509917:37,553,136G/Aupstream gene variant
rs1260075117:37,553,651G/Cupstream gene variant
rs990543217:37,555,918C/T

Gene information from NCBI Gene. Variant classifications from ClinVar.