FCER2
Fc epsilon receptor II
Summary
The protein encoded by this gene is a B-cell specific antigen, and a low-affinity receptor for IgE. It has essential roles in B cell growth and differentiation, and the regulation of IgE production. This protein also exists as a soluble secreted form, then functioning as a potent mitogenic growth factor. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]
Known Variants33 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs145467617 | 19:7,754,129 | G/A | — | uncertain significance |
| rs145983387 | 19:7,754,221 | C/T | — | uncertain significance |
| rs376018958 | 19:7,754,233 | G/T | — | uncertain significance |
| rs548023601 | 19:7,754,245 | C/G | — | uncertain significance |
| rs777512868 | 19:7,754,257 | C/T | — | likely benign |
| rs767049788 | 19:7,754,309 | C/A | — | uncertain significance |
| rs144339823 | 19:7,755,117 | G/A | — | uncertain significance |
| rs28364072 | 19:7,755,285 | A/G | splice region variant | — |
| rs377564979 | 19:7,755,297 | C/T | — | uncertain significance |
| rs758952802 | 19:7,755,327 | C/T | — | uncertain significance |
| rs1400063852 | 19:7,755,393 | A/T | — | uncertain significance |
| rs12973524 | 19:7,758,263 | G/T | — | — |
| rs12460997 | 19:7,758,793 | C/G | — | — |
| rs189294179 | 19:7,759,469 | G/T | regulatory region variant | — |
| rs11260014 | 19:7,759,715 | G/T | — | — |
| rs1379085751 | 19:7,761,722 | T/G | — | uncertain significance |
| rs375613452 | 19:7,761,756 | G/A | — | uncertain significance |
| rs767026479 | 19:7,761,935 | C/T | — | likely benign |
| rs961384969 | 19:7,762,133 | A/G | — | uncertain significance |
| rs779315614 | 19:7,762,176 | T/C | — | uncertain significance |
| rs2033049640 | 19:7,762,438 | A/C | — | likely benign |
| rs765399497 | 19:7,762,458 | T/C | — | likely benign |
| rs7249320 | 19:7,763,045 | C/A | intron variant | — |
| rs2228137 | 19:7,763,248 | G/C | missense variant | — |
| rs778561468 | 19:7,763,286 | G/A | — | uncertain significance |
| rs193197320 | 19:7,763,653 | C/T | — | uncertain significance |
| rs754758835 | 19:7,763,666 | C/T | — | uncertain significance |
| rs745892615 | 19:7,763,671 | G/A | — | uncertain significance |
| rs758552077 | 19:7,763,680 | C/T | — | uncertain significance |
| rs770161837 | 19:7,763,704 | C/T | — | uncertain significance |
| rs138026836 | 19:7,763,735 | C/T | — | uncertain significance |
| rs543972514 | 19:7,767,074 | C/A | — | — |
| rs3760687 | 19:7,767,394 | C/T | regulatory region variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.