FCGR3B
Fc gamma receptor IIIb
Summary
The protein encoded by this gene is a low affinity receptor for the Fc region of gamma immunoglobulins (IgG). The encoded protein acts as a monomer and can bind either monomeric or aggregated IgG. This gene may function to capture immune complexes in the peripheral circulation. Several transcript variants encoding different isoforms have been found for this gene. A highly-similar gene encoding a related protein is also found on chromosome 1. [provided by RefSeq, Aug 2012]
Known Variants34 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs145335641 | 1:161,592,675 | G/C | — | — |
| rs747954960 | 1:161,594,327 | A/T | — | uncertain significance |
| rs540459343 | 1:161,594,358 | G/C | — | uncertain significance |
| rs138362091 | 1:161,594,424 | C/T | — | uncertain significance |
| rs142480337 | 1:161,594,558 | G/A | regulatory region variant | — |
| rs61803013 | 1:161,594,761 | T/A | — | — |
| rs1279742492 | 1:161,595,936 | T/G | — | uncertain significance |
| rs200215055 | 1:161,595,986 | C/A | — | likely benign |
| rs188904436 | 1:161,596,010 | C/T | — | uncertain significance |
| rs200914601 | 1:161,596,028 | C/T | — | uncertain significance |
| rs71632958 | 1:161,596,040 | G/A | — | likely benign |
| rs547946059 | 1:161,596,100 | T/C | — | uncertain significance |
| rs568134732 | 1:161,596,102 | T/G | — | uncertain significance |
| rs150392443 | 1:161,598,898 | T/G | intron variant | — |
| rs2290834 | 1:161,599,571 | T/C | missense variant | benign |
| rs200303549 | 1:161,599,575 | G/T | — | benign |
| rs267598137 | 1:161,599,591 | G/A | — | uncertain significance |
| rs370893367 | 1:161,599,597 | C/T | — | uncertain significance |
| rs371151798 | 1:161,599,638 | G/C | — | uncertain significance |
| rs147574249 | 1:161,599,643 | T/A | missense variant | no classification for the single variant |
| rs2524658367 | 1:161,599,652 | C/T | — | uncertain significance |
| rs5030738 | 1:161,599,654 | G/A | missense variant | — |
| rs448740 | 1:161,599,693 | T/C | missense variant | pathogenic |
| rs368910826 | 1:161,599,717 | G/A | — | uncertain significance |
| rs1209332043 | 1:161,599,720 | T/C | — | uncertain significance |
| rs200688856 | 1:161,599,779 | G/C | missense variant | no classification for the single variant |
| rs201534974 | 1:161,599,808 | C/G | — | uncertain significance |
| rs546592367 | 1:161,599,831 | G/T | — | likely benign |
| rs781498971 | 1:161,600,166 | A/G | — | likely benign |
| rs111402007 | 1:161,600,189 | A/G | intron variant | — |
| rs513242 | 1:161,600,521 | C/T | — | — |
| rs72704050 | 1:161,600,592 | G/A | intron variant | — |
| rs61803029 | 1:161,601,521 | G/A | upstream gene variant | — |
| rs112909486 | 1:161,602,163 | A/C | — | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.