FCHSD2
FCH and double SH3 domains 2
Summary
Enables phosphatidylinositol-3,4,5-trisphosphate binding activity and phosphatidylinositol-3,4-bisphosphate binding activity. Involved in clathrin-dependent endocytosis and positive regulation of Arp2/3 complex-mediated actin nucleation. Located in clathrin-coated pit and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Known Variants51 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs181961231 | 11:72,549,864 | A/G | — | uncertain significance |
| rs760772829 | 11:72,549,904 | G/C | — | uncertain significance |
| rs146015778 | 11:72,551,933 | T/G | — | uncertain significance |
| rs776775518 | 11:72,551,992 | T/A | — | uncertain significance |
| rs555444484 | 11:72,552,516 | C/G | — | uncertain significance |
| rs114942058 | 11:72,552,585 | G/A | — | benign |
| rs1365825253 | 11:72,553,753 | A/T | — | uncertain significance |
| rs751572265 | 11:72,553,763 | C/G | — | uncertain significance |
| rs762002880 | 11:72,554,226 | C/T | — | uncertain significance |
| rs766473899 | 11:72,554,325 | G/T | — | uncertain significance |
| rs576568698 | 11:72,560,874 | C/T | — | uncertain significance |
| rs767103922 | 11:72,560,875 | G/T | — | uncertain significance |
| rs368659761 | 11:72,560,885 | A/G | — | uncertain significance |
| rs779505143 | 11:72,560,908 | T/G | — | uncertain significance |
| rs753766433 | 11:72,560,909 | T/C | — | uncertain significance |
| rs778603874 | 11:72,560,919 | C/T | — | uncertain significance |
| rs140557765 | 11:72,578,911 | G/A | — | uncertain significance |
| rs142899648 | 11:72,578,956 | C/T | — | uncertain significance |
| rs745363284 | 11:72,578,990 | T/C | — | uncertain significance |
| rs372956797 | 11:72,579,028 | T/C | — | uncertain significance |
| rs775098553 | 11:72,579,046 | C/T | — | uncertain significance |
| rs77605839 | 11:72,579,066 | A/G | — | benign |
| rs144631789 | 11:72,579,070 | A/G | — | uncertain significance |
| rs78063789 | 11:72,588,020 | A/T | intron variant | — |
| rs148444805 | 11:72,598,592 | C/T | — | uncertain significance |
| rs752903498 | 11:72,598,600 | C/A | — | uncertain significance |
| rs142618697 | 11:72,598,601 | A/C | — | uncertain significance |
| rs140393712 | 11:72,600,884 | T/C | — | uncertain significance |
| rs2497624163 | 11:72,600,932 | G/A | — | uncertain significance |
| rs139052840 | 11:72,613,612 | C/G | — | uncertain significance |
| rs773389977 | 11:72,613,626 | G/A | — | uncertain significance |
| rs766938793 | 11:72,613,641 | C/T | — | uncertain significance |
| rs2497665023 | 11:72,613,674 | C/T | — | uncertain significance |
| rs1565324042 | 11:72,632,897 | C/A | — | uncertain significance |
| rs1225444368 | 11:72,632,941 | G/A | — | uncertain significance |
| rs77971648 | 11:72,640,480 | T/C | intron variant | — |
| rs72981516 | 11:72,670,900 | T/G | intron variant | — |
| rs377537934 | 11:72,695,191 | G/A | — | uncertain significance |
| rs963539344 | 11:72,695,219 | C/T | — | uncertain significance |
| rs775616333 | 11:72,700,111 | T/G | — | uncertain significance |
| rs1290863356 | 11:72,700,116 | T/A | — | uncertain significance |
| rs553192291 | 11:72,707,389 | C/T | — | — |
| rs77175727 | 11:72,712,037 | T/G | — | benign |
| rs368880489 | 11:72,712,093 | T/C | — | uncertain significance |
| rs771880379 | 11:72,712,169 | G/A | — | uncertain significance |
| rs2497989584 | 11:72,712,174 | A/G | — | uncertain significance |
| rs1341367344 | 11:72,712,175 | T/A | — | uncertain significance |
| rs2886599 | 11:72,721,271 | C/A | intron variant | — |
| rs569167163 | 11:72,726,866 | C/T | — | uncertain significance |
| rs141187345 | 11:72,755,643 | T/A | intron variant | — |
| rs139395844 | 11:72,838,513 | A/C | intron variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.