FCRL4
Fc receptor like 4
Summary
This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein has four extracellular C2-type immunoglobulin domains, a transmembrane domain and a cytoplasmic domain that contains three immune-receptor tyrosine-based inhibitory motifs. This protein may play a role in the function of memory B-cells in the epithelia. Aberrations in the chromosomal region encoding this gene are associated with non-Hodgkin lymphoma and multiple myeloma. [provided by RefSeq, Apr 2009]
Known Variants33 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs1346764150 | 1:157,545,369 | G/A | — | uncertain significance |
| rs539336487 | 1:157,547,562 | G/T | — | — |
| rs2526344442 | 1:157,548,302 | G/C | — | uncertain significance |
| rs2039401 | 1:157,548,323 | T/C | — | benign |
| rs772089801 | 1:157,548,619 | C/A | — | uncertain significance |
| rs144706531 | 1:157,550,119 | G/C | — | uncertain significance |
| rs1278447400 | 1:157,550,120 | T/C | — | uncertain significance |
| rs540929035 | 1:157,550,129 | A/G | — | uncertain significance |
| rs143384661 | 1:157,551,349 | C/G | — | benign |
| rs146229190 | 1:157,555,970 | C/T | — | likely benign |
| rs138116291 | 1:157,556,009 | C/T | — | uncertain significance |
| rs777768681 | 1:157,556,030 | C/G | — | uncertain significance |
| rs2101681637 | 1:157,556,047 | A/T | — | uncertain significance |
| rs761378641 | 1:157,556,081 | G/A | — | uncertain significance |
| rs2526366562 | 1:157,556,102 | T/C | — | uncertain significance |
| rs779431310 | 1:157,556,153 | C/T | — | uncertain significance |
| rs576521453 | 1:157,556,194 | G/A | — | likely benign |
| rs75246959 | 1:157,556,262 | C/A | intron variant | — |
| rs2777963 | 1:157,556,532 | G/A | intron variant | — |
| rs147815493 | 1:157,557,065 | C/T | — | uncertain significance |
| rs763126889 | 1:157,557,090 | G/T | — | uncertain significance |
| rs4561035 | 1:157,557,149 | T/C | — | benign |
| rs372713823 | 1:157,557,183 | G/C | — | uncertain significance |
| rs768508139 | 1:157,557,264 | G/A | — | uncertain significance |
| rs144386002 | 1:157,557,269 | T/C | — | uncertain significance |
| rs140418584 | 1:157,557,301 | C/A | — | uncertain significance |
| rs752639258 | 1:157,557,684 | C/T | — | likely benign |
| rs1652740359 | 1:157,557,691 | C/T | — | uncertain significance |
| rs774005304 | 1:157,557,790 | G/T | — | likely benign |
| rs755030060 | 1:157,557,860 | C/G | — | uncertain significance |
| rs150278458 | 1:157,559,039 | G/A | — | uncertain significance |
| rs113916332 | 1:157,559,349 | T/C | intron variant | — |
| rs78950792 | 1:157,568,414 | T/C | regulatory region variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.