FGD6
FYVE, RhoGEF and PH domain containing 6
Summary
Predicted to enable guanyl-nucleotide exchange factor activity and small GTPase binding activity. Predicted to be involved in actin cytoskeleton organization; filopodium assembly; and regulation of cell shape. Predicted to be located in Golgi apparatus; lamellipodium; and ruffle. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Known Variants85 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs1877800114 | 12:95,478,419 | C/T | — | uncertain significance |
| rs181557983 | 12:95,479,630 | C/T | — | uncertain significance |
| rs12310399 | 12:95,490,248 | T/G | — | — |
| rs4762479 | 12:95,495,041 | C/T | downstream gene variant | — |
| rs369997798 | 12:95,498,821 | C/G | — | uncertain significance |
| rs146989434 | 12:95,501,352 | C/G | — | uncertain significance |
| rs371288810 | 12:95,502,192 | T/C | — | uncertain significance |
| rs11107903 | 12:95,507,971 | G/A | intron variant | — |
| rs12578168 | 12:95,511,321 | G/A | regulatory region variant | — |
| rs10859834 | 12:95,512,141 | A/T | — | — |
| rs34539435 | 12:95,514,982 | G/C | — | — |
| rs11107908 | 12:95,521,242 | C/T | downstream gene variant | — |
| rs1879706435 | 12:95,531,369 | T/C | — | uncertain significance |
| rs79252275 | 12:95,535,156 | A/C | — | benign |
| rs769977036 | 12:95,535,204 | G/A | — | uncertain significance |
| rs866176024 | 12:95,535,215 | T/C | — | uncertain significance |
| rs773368153 | 12:95,535,255 | G/A | — | uncertain significance |
| rs12369441 | 12:95,536,949 | T/C | intron variant | — |
| rs60129850 | 12:95,538,021 | C/A | intron variant | — |
| rs191808719 | 12:95,546,621 | T/A | — | benign |
| rs200992986 | 12:95,546,739 | G/A | — | uncertain significance |
| rs754051793 | 12:95,546,753 | A/C | — | uncertain significance |
| rs11107916 | 12:95,556,116 | T/A | — | — |
| rs765499872 | 12:95,566,402 | C/T | — | uncertain significance |
| rs756959651 | 12:95,566,475 | G/T | — | uncertain significance |
| rs774885571 | 12:95,566,518 | G/A | — | uncertain significance |
| rs7135847 | 12:95,577,670 | C/T | intron variant | — |
| rs7309426 | 12:95,592,272 | G/T | — | — |
| rs1390270756 | 12:95,602,670 | T/C | — | uncertain significance |
| rs2547149603 | 12:95,602,676 | T/A | — | uncertain significance |
| rs146107062 | 12:95,602,803 | G/A | — | uncertain significance |
| rs547330440 | 12:95,602,806 | G/A | — | uncertain significance |
| rs757525900 | 12:95,602,823 | G/A | — | uncertain significance |
| rs1480674292 | 12:95,602,829 | C/G | — | uncertain significance |
| rs372025806 | 12:95,602,916 | T/C | — | uncertain significance |
| rs747265949 | 12:95,602,938 | G/A | — | uncertain significance |
| rs759320173 | 12:95,603,006 | C/A | — | uncertain significance |
| rs763573273 | 12:95,603,025 | C/A | — | uncertain significance |
| rs199618758 | 12:95,603,097 | C/T | — | uncertain significance |
| rs535014275 | 12:95,603,142 | T/A | — | uncertain significance |
| rs766816123 | 12:95,603,166 | T/C | — | uncertain significance |
| rs758372859 | 12:95,603,223 | T/G | — | uncertain significance |
| rs773048074 | 12:95,603,409 | C/T | — | likely benign |
| rs2056713290 | 12:95,603,418 | T/G | — | uncertain significance |
| rs2056713312 | 12:95,603,419 | T/G | — | uncertain significance |
| rs2056713330 | 12:95,603,420 | T/G | — | likely benign |
| rs751475528 | 12:95,603,427 | A/G | — | uncertain significance |
| rs748982798 | 12:95,603,455 | A/T | — | uncertain significance |
| rs760891402 | 12:95,603,481 | T/G | — | uncertain significance |
| rs762070123 | 12:95,603,514 | C/T | — | uncertain significance |
| rs200898390 | 12:95,603,571 | T/G | — | uncertain significance |
| rs368077081 | 12:95,603,727 | C/T | — | likely benign |
| rs764184866 | 12:95,603,801 | T/A | — | uncertain significance |
| rs1403969107 | 12:95,603,805 | C/T | — | uncertain significance |
| rs765799838 | 12:95,603,849 | A/G | — | uncertain significance |
| rs78481495 | 12:95,603,852 | G/A | — | benign |
| rs926233126 | 12:95,603,853 | C/T | — | uncertain significance |
| rs1040127869 | 12:95,603,948 | T/C | — | uncertain significance |
| rs200395883 | 12:95,603,963 | T/C | — | uncertain significance |
| rs773122761 | 12:95,603,976 | T/C | — | uncertain significance |
| rs765994336 | 12:95,603,995 | A/T | — | uncertain significance |
| rs754288500 | 12:95,604,038 | G/A | — | uncertain significance |
| rs1231800261 | 12:95,604,052 | T/G | — | uncertain significance |
| rs201840186 | 12:95,604,089 | C/T | — | uncertain significance |
| rs77642937 | 12:95,604,233 | T/C | — | uncertain significance |
| rs143434217 | 12:95,604,270 | T/C | — | uncertain significance |
| rs546691625 | 12:95,604,272 | C/T | — | uncertain significance |
| rs139502708 | 12:95,604,321 | T/C | — | uncertain significance |
| rs141232857 | 12:95,604,377 | G/T | — | conflicting classifications of pathogenicity |
| rs35478339 | 12:95,604,444 | G/A | — | uncertain significance |
| rs146520684 | 12:95,604,446 | C/T | — | likely benign |
| rs1365314215 | 12:95,604,477 | T/C | — | uncertain significance |
| rs200392285 | 12:95,604,487 | C/T | — | uncertain significance |
| rs1306976093 | 12:95,604,510 | T/G | — | uncertain significance |
| rs545010957 | 12:95,604,520 | T/G | — | uncertain significance |
| rs141186779 | 12:95,604,528 | C/T | — | likely benign |
| rs77713622 | 12:95,604,735 | T/C | — | likely benign |
| rs1185160253 | 12:95,604,746 | T/C | — | uncertain significance |
| rs1019993614 | 12:95,604,759 | G/T | — | uncertain significance |
| rs374659707 | 12:95,604,762 | T/G | — | likely benign |
| rs2547151288 | 12:95,604,830 | A/G | — | uncertain significance |
| rs764651789 | 12:95,604,908 | G/A | — | uncertain significance |
| rs771166655 | 12:95,604,972 | T/C | — | likely benign |
| rs776559475 | 12:95,605,004 | A/G | — | uncertain significance |
| rs148621935 | 12:95,605,023 | C/T | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.