FGF10
fibroblast growth factor 10
Summary
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein exhibits mitogenic activity for keratinizing epidermal cells, but essentially no activity for fibroblasts, which is similar to the biological activity of FGF7. Studies of the mouse homolog of suggested that this gene is required for embryonic epidermal morphogenesis including brain development, lung morphogenesis, and initiation of lim bud formation. This gene is also implicated to be a primary factor in the process of wound healing. [provided by RefSeq, Jul 2008]
Known Variants79 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs13186320 | 5:44,302,177 | A/G | — | — |
| rs768184879 | 5:44,304,004 | T/C | — | pathogenic |
| rs2478332415 | 5:44,304,374 | G/T | — | uncertain significance |
| rs111763965 | 5:44,305,092 | T/A | — | likely benign |
| rs886060653 | 5:44,305,100 | T/C | — | conflicting classifications of pathogenicity |
| rs147715509 | 5:44,305,104 | T/G | — | likely benign |
| rs773535125 | 5:44,305,111 | C/T | — | uncertain significance |
| rs150695565 | 5:44,305,114 | T/C | — | conflicting classifications of pathogenicity |
| rs17234639 | 5:44,305,133 | G/A | — | benign |
| rs1418284908 | 5:44,305,143 | C/T | — | uncertain significance |
| rs104893884 | 5:44,305,147 | G/A | stop gained | pathogenic |
| rs1740045309 | 5:44,305,171 | C/T | — | uncertain significance |
| rs1554035469 | 5:44,305,174 | C/T | — | likely pathogenic |
| rs1332768200 | 5:44,305,183 | T/G | — | uncertain significance |
| rs2478335585 | 5:44,305,185 | A/G | — | uncertain significance |
| rs2478335727 | 5:44,305,197 | A/G | — | uncertain significance |
| rs104893886 | 5:44,305,257 | A/C | missense variant | pathogenic |
| rs748739422 | 5:44,305,271 | C/G | — | uncertain significance |
| rs2290070 | 5:44,305,309 | C/G | — | benign |
| rs17228255 | 5:44,305,374 | T/C | — | likely benign |
| rs6451758 | 5:44,305,515 | T/A | — | benign |
| rs10462070 | 5:44,305,749 | A/G | intron variant | — |
| rs17228123 | 5:44,310,249 | A/G | — | likely benign |
| rs6881797 | 5:44,310,492 | A/T | — | benign |
| rs149851674 | 5:44,310,532 | G/A | — | likely benign |
| rs202058604 | 5:44,310,535 | A/G | — | conflicting classifications of pathogenicity |
| rs104893889 | 5:44,310,545 | C/T | missense variant | pathogenic |
| rs104893887 | 5:44,310,549 | T/A | stop gained | pathogenic |
| rs1554035757 | 5:44,310,557 | A/T | — | likely pathogenic |
| rs2478349923 | 5:44,310,584 | G/T | — | likely pathogenic |
| rs776683911 | 5:44,310,591 | C/T | — | uncertain significance |
| rs1740186895 | 5:44,310,603 | C/T | — | likely pathogenic |
| rs201385181 | 5:44,310,604 | G/A | — | likely benign |
| rs13170645 | 5:44,329,203 | G/A | intron variant | — |
| rs1011814 | 5:44,335,820 | T/C | intron variant | — |
| rs4866893 | 5:44,339,984 | G/A | intron variant | — |
| rs1448037 | 5:44,352,344 | T/C | intron variant | — |
| rs1374970 | 5:44,353,985 | G/A | intron variant | — |
| rs12517396 | 5:44,359,526 | C/A | intron variant | — |
| rs10941664 | 5:44,362,134 | C/T | intron variant | — |
| rs339502 | 5:44,364,007 | A/G | — | — |
| rs78732306 | 5:44,365,078 | T/C | intron variant | — |
| rs2121875 | 5:44,365,545 | C/A | regulatory region variant | benign |
| rs339501 | 5:44,365,633 | C/T | regulatory region variant | — |
| rs16874036 | 5:44,366,552 | G/A | intron variant | — |
| rs6859730 | 5:44,367,221 | A/C | — | — |
| rs11750845 | 5:44,373,060 | C/T | intron variant | — |
| rs10805683 | 5:44,375,270 | C/A | — | — |
| rs16901825 | 5:44,385,395 | T/C | upstream gene variant | — |
| rs1482679 | 5:44,385,415 | A/G | — | benign |
| rs145059362 | 5:44,388,445 | G/T | — | benign |
| rs775751673 | 5:44,388,448 | T/G | — | likely benign |
| rs991153960 | 5:44,388,452 | T/C | — | likely benign |
| rs104893885 | 5:44,388,468 | C/A | missense variant | pathogenic |
| rs545941601 | 5:44,388,524 | C/T | — | benign |
| rs104893888 | 5:44,388,545 | T/G | missense variant | pathogenic |
| rs2478542924 | 5:44,388,548 | C/T | — | pathogenic |
| rs149009979 | 5:44,388,569 | G/A | — | likely benign |
| rs201676495 | 5:44,388,594 | C/A | — | uncertain significance |
| rs1446723373 | 5:44,388,595 | C/A | — | pathogenic |
| rs886060654 | 5:44,388,599 | G/T | — | uncertain significance |
| rs775259892 | 5:44,388,630 | G/T | — | uncertain significance |
| rs886060655 | 5:44,388,641 | C/T | — | uncertain significance |
| rs2478543573 | 5:44,388,652 | C/G | — | uncertain significance |
| rs201168313 | 5:44,388,655 | T/C | — | uncertain significance |
| rs201790067 | 5:44,388,669 | G/T | — | uncertain significance |
| rs2478543701 | 5:44,388,673 | G/C | — | uncertain significance |
| rs1742166191 | 5:44,388,676 | A/G | — | uncertain significance |
| rs140279180 | 5:44,388,683 | A/C | — | likely benign |
| rs145373611 | 5:44,388,688 | C/T | — | likely benign |
| rs200247528 | 5:44,388,721 | A/G | — | conflicting classifications of pathogenicity |
| rs2111940905 | 5:44,388,725 | G/A | — | likely benign |
| rs766097540 | 5:44,388,737 | C/T | — | likely benign |
| rs148032639 | 5:44,388,744 | G/A | — | uncertain significance |
| rs747476439 | 5:44,388,769 | G/T | — | uncertain significance |
| rs2111941241 | 5:44,388,775 | A/G | — | uncertain significance |
| rs1554040396 | 5:44,388,784 | T/C | — | likely pathogenic |
| rs143865624 | 5:44,388,794 | A/T | — | uncertain significance |
| rs17233910 | 5:44,388,817 | C/T | — | benign |
Gene information from NCBI Gene. Variant classifications from ClinVar.