rs10941664

This is a intron variant variant in the FGF10 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

acne

Teder-Laving M et al. “Genome-wide meta-analysis identifies novel loci conferring risk of acne vulgaris.” European Journal of Human Genetics : Ejhg 32(9):1136-1143 (2024)
Allele C
OR 1.06
p 2.0e-8
N 399,413
Meta-analysisLarge GWAS
European

About FGF10

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein exhibits mitogenic activity for keratinizing epidermal cells, but essentially no activity for fibroblasts, which is similar to the biological activity of FGF7. Studies of the mouse homolog of suggested that this gene is required for embryonic epidermal morphogenesis including brain development, lung morphogenesis, and initiation of lim bud formation. This gene is also implicated to be a primary factor in the process of wound healing. [provided by RefSeq, Jul 2008]

View all FGF10 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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