FGG
fibrinogen gamma chain
Summary
The protein encoded by this gene is the gamma component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia and thrombophilia. Alternative splicing results in transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]
Known Variants127 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs2066865 | 4:155,525,276 | G/A | downstream gene variant | benign |
| rs146143405 | 4:155,525,451 | T/C | — | likely benign |
| rs183036893 | 4:155,525,486 | G/A | — | uncertain significance |
| rs187316301 | 4:155,525,490 | T/G | — | conflicting classifications of pathogenicity |
| rs1731056413 | 4:155,525,492 | T/C | — | uncertain significance |
| rs191297318 | 4:155,525,498 | G/A | — | conflicting classifications of pathogenicity |
| rs375111958 | 4:155,525,506 | C/A | — | uncertain significance |
| rs2066880 | 4:155,525,545 | A/T | — | benign |
| rs2066864 | 4:155,525,695 | G/A | — | benign |
| rs1049636 | 4:155,525,970 | G/A | 3 prime UTR variant | — |
| rs141597421 | 4:155,526,029 | G/A | — | conflicting classifications of pathogenicity |
| rs2530852623 | 4:155,526,048 | C/A | — | uncertain significance |
| rs145938787 | 4:155,526,063 | C/A | — | uncertain significance |
| rs1036477853 | 4:155,526,075 | G/T | — | uncertain significance |
| rs374917187 | 4:155,526,090 | T/C | — | uncertain significance |
| rs886059154 | 4:155,526,111 | T/C | — | uncertain significance |
| rs587777720 | 4:155,526,138 | A/G | missense variant | pathogenic |
| rs2110838894 | 4:155,526,146 | C/T | — | uncertain significance |
| rs75848804 | 4:155,526,147 | G/A | missense variant | pathogenic |
| rs2530852903 | 4:155,526,149 | G/C | — | likely benign |
| rs1731071910 | 4:155,526,158 | G/A | — | uncertain significance |
| rs2530852957 | 4:155,526,176 | T/A | — | likely pathogenic |
| rs121913095 | 4:155,526,180 | C/G | missense variant | other |
| rs1021492173 | 4:155,526,201 | C/G | — | uncertain significance |
| rs2530853032 | 4:155,526,210 | A/T | — | uncertain significance |
| rs369271819 | 4:155,526,218 | C/A | — | uncertain significance |
| rs2066878 | 4:155,526,231 | G/A | — | benign |
| rs2066877 | 4:155,527,145 | C/T | — | benign |
| rs2066862 | 4:155,527,225 | C/T | — | conflicting classifications of pathogenicity |
| rs2066861 | 4:155,527,436 | C/T | regulatory region variant | benign |
| rs796623803 | 4:155,527,793 | A/G | — | benign |
| rs766524002 | 4:155,527,861 | G/A | — | uncertain significance |
| rs78257946 | 4:155,527,887 | C/T | — | conflicting classifications of pathogenicity |
| rs2530855709 | 4:155,527,899 | T/C | — | uncertain significance |
| rs2110841438 | 4:155,527,900 | C/T | — | conflicting classifications of pathogenicity |
| rs121913094 | 4:155,527,919 | T/A | missense variant | likely pathogenic |
| rs121913093 | 4:155,527,920 | C/A | missense variant | other |
| rs121913092 | 4:155,527,922 | T/C | missense variant | other |
| rs2530855793 | 4:155,527,949 | T/C | — | likely pathogenic |
| rs1578808495 | 4:155,527,951 | A/G | — | likely benign |
| rs2530855833 | 4:155,527,953 | T/G | — | uncertain significance |
| rs1553965518 | 4:155,527,956 | C/T | — | likely pathogenic |
| rs1553965519 | 4:155,527,964 | C/T | — | pathogenic |
| rs2530855860 | 4:155,527,967 | G/A | — | likely pathogenic |
| rs2530855866 | 4:155,527,971 | T/C | — | uncertain significance |
| rs121913091 | 4:155,527,979 | A/G | missense variant | pathogenic |
| rs1578808538 | 4:155,527,984 | A/C | — | other |
| rs121913090 | 4:155,527,985 | T/A | missense variant | uncertain significance |
| rs146218442 | 4:155,528,020 | G/A | — | likely benign |
| rs121913089 | 4:155,528,033 | C/A | missense variant | uncertain significance |
| rs267606810 | 4:155,528,034 | C/T | — | uncertain significance |
| rs121913096 | 4:155,528,060 | C/T | missense variant | other |
| rs139133145 | 4:155,528,064 | C/T | — | uncertain significance |
| rs529366098 | 4:155,528,065 | G/A | — | benign |
| rs121913088 | 4:155,528,084 | C/T | missense variant | pathogenic |
| rs121913087 | 4:155,528,085 | G/A | missense variant | pathogenic |
| rs2530856270 | 4:155,528,120 | G/A | — | uncertain significance |
| rs754623069 | 4:155,529,643 | G/A | — | likely benign |
| rs771279321 | 4:155,529,676 | G/A | — | uncertain significance |
| rs1363396777 | 4:155,529,684 | A/T | — | uncertain significance |
| rs757602733 | 4:155,529,699 | T/G | — | uncertain significance |
| rs764126419 | 4:155,529,701 | A/G | — | likely benign |
| rs937512126 | 4:155,529,749 | T/A | — | likely benign |
| rs1553965666 | 4:155,529,756 | T/C | — | uncertain significance |
| rs762488338 | 4:155,529,760 | A/G | — | conflicting classifications of pathogenicity |
| rs2110844651 | 4:155,529,769 | A/G | — | uncertain significance |
| rs2110844685 | 4:155,529,775 | T/C | — | uncertain significance |
| rs1383020932 | 4:155,529,778 | T/C | — | uncertain significance |
| rs754328933 | 4:155,529,784 | C/T | — | uncertain significance |
| rs757702704 | 4:155,529,786 | A/G | — | uncertain significance |
| rs1310452604 | 4:155,529,792 | C/A | — | conflicting classifications of pathogenicity |
| rs1260834809 | 4:155,529,795 | T/A | — | uncertain significance |
| rs886059155 | 4:155,529,812 | C/G | — | uncertain significance |
| rs587776839 | 4:155,530,122 | T/A | — | pathogenic |
| rs1578810856 | 4:155,530,759 | A/T | — | pathogenic |
| rs2530861236 | 4:155,530,762 | C/A | — | likely benign |
| rs756786962 | 4:155,530,765 | G/A | — | likely benign |
| rs2530861293 | 4:155,530,787 | G/T | — | uncertain significance |
| rs747416023 | 4:155,530,795 | G/A | — | uncertain significance |
| rs1279314456 | 4:155,530,796 | T/C | — | uncertain significance |
| rs748194040 | 4:155,530,815 | A/C | — | uncertain significance |
| rs1578810954 | 4:155,530,826 | A/G | — | uncertain significance |
| rs775086103 | 4:155,530,828 | T/C | — | uncertain significance |
| rs2110846559 | 4:155,530,842 | C/G | — | uncertain significance |
| rs2530861514 | 4:155,530,865 | T/G | — | uncertain significance |
| rs761289445 | 4:155,530,876 | C/T | — | uncertain significance |
| rs6063 | 4:155,530,877 | C/T | missense variant | pathogenic |
| rs2110846745 | 4:155,530,913 | A/C | — | uncertain significance |
| rs577663651 | 4:155,530,932 | G/A | — | likely benign |
| rs141651129 | 4:155,530,958 | G/A | — | benign |
| rs371692602 | 4:155,531,248 | G/A | — | uncertain significance |
| rs141559764 | 4:155,531,249 | T/C | — | uncertain significance |
| rs750418989 | 4:155,531,292 | C/T | — | likely benign |
| rs751435976 | 4:155,531,304 | G/T | — | uncertain significance |
| rs2066870 | 4:155,531,333 | A/G | — | likely benign |
| rs201708362 | 4:155,532,942 | A/G | — | likely benign |
| rs764559342 | 4:155,532,957 | C/T | — | uncertain significance |
| rs2530865838 | 4:155,533,024 | A/G | — | uncertain significance |
| rs1578812509 | 4:155,533,027 | T/A | — | pathogenic |
| rs148685782 | 4:155,533,035 | G/C | — | conflicting classifications of pathogenicity |
Showing 100 of 127 variants. Use the SNP search for the full list.
Gene information from NCBI Gene. Variant classifications from ClinVar.