Trait
SNPs associated with Heart Disease
89 genetic variants across 42 genes have been associated with Heart Disease in published research. Key genes include ABCG8, ABO, ANGPTL4.
Associated variants89 total
| rsid | Gene | Effect | Evidence |
|---|---|---|---|
| rs10455872 | LPA | GWAS association (p=3.0e-165) | Major Consortium Study |
| rs1537373 | CDKN2B-AS1 | GWAS association (p=7.0e-143) | Major Consortium Study |
| rs9349379 | PHACTR1 | GWAS association (p=5.0e-73) | Major Consortium Study |
| rs583104 | — | GWAS association (p=3.0e-69) | Major Consortium Study |
| rs3756011 | — | GWAS association (p=6.0e-68) | Major Consortium Study |
| rs7528419 | CELSR2 | GWAS association (p=7.0e-46) | Major Consortium Study |
| rs9980618 | — | GWAS association (p=2.0e-45) | Major Consortium Study |
| rs2066864 | FGG | GWAS association (p=5.0e-45) | Major Consortium Study |
| rs4253417 | — | GWAS association (p=4.0e-43) | Major Consortium Study |
| rs9515203 | COL4A2 | GWAS association (p=7.0e-42) | Major Consortium Study |
| rs964184 | APOA5 | GWAS association (p=2.0e-30) | Major Consortium Study |
| rs10176176 | — | GWAS association (p=2.0e-29) | Major Consortium Study |
| rs494207 | — | GWAS association (p=2.0e-28) | Major Consortium Study |
| rs78707713 | TSPAN15 | GWAS association (p=3.0e-27) | Major Consortium Study |
| rs28451064 | — | GWAS association (p=3.0e-27) | Major Consortium Study |
| rs12190287 | TCF21 | GWAS association (p=4.0e-27) | Major Consortium Study |
| rs429358 | APOE | GWAS association (p=1.0e-26) | Major Consortium Study |
| rs11556924 | ZC3HC1 | GWAS association (p=4.0e-25) | Major Consortium Study |
| rs142130958 | — | GWAS association (p=1.0e-24) | Major Consortium Study |
| rs7500448 | — | GWAS association (p=3.0e-24) | Major Consortium Study |
| rs2019090 | — | GWAS association (p=2.0e-23) | Major Consortium Study |
| rs2681492 | ATP2B1 | GWAS association (p=1.0e-22) | Major Consortium Study |
| rs73855814 | — | GWAS association (p=1.0e-22) | Major Consortium Study |
| rs2954021 | — | GWAS association (p=3.0e-22) | Major Consortium Study |
| rs1065853 | — | GWAS association (p=4.0e-22) | Major Consortium Study |
| rs12573103 | — | GWAS association (p=8.0e-22) | Major Consortium Study |
| rs73045269 | — | GWAS association (p=7.0e-21) | Major Consortium Study |
| rs62012629 | — | GWAS association (p=1.0e-20) | Major Consortium Study |
| rs72932780 | ICA1L | GWAS association (p=1.0e-19) | Major Consortium Study |
| rs11591147 | PCSK9 | GWAS association (p=5.0e-19) | Major Consortium Study |
| rs9797854 | SLC44A2 | GWAS association (p=9.0e-19) | Major Consortium Study |
| rs10495198 | MIA3 | GWAS association (p=3.0e-18) | Major Consortium Study |
| rs10846744 | SCARB1 | GWAS association (p=4.0e-18) | Major Consortium Study |
| rs77870048 | — | GWAS association (p=4.0e-17) | Major Consortium Study |
| rs1412445 | LIPA | GWAS association (p=4.0e-17) | Major Consortium Study |
| rs3918226 | NOS3 | GWAS association (p=5.0e-17) | Major Consortium Study |
| rs3916027 | LPL | GWAS association (p=6.0e-17) | Major Consortium Study |
| rs2378335 | MMP24-AS1-EDEM2 | GWAS association (p=8.0e-17) | Major Consortium Study |
| rs7165042 | — | GWAS association (p=8.0e-17) | Major Consortium Study |
| rs11670056 | — | GWAS association (p=1.0e-16) | Major Consortium Study |
| rs10747514 | — | GWAS association (p=3.0e-15) | Major Consortium Study |
| rs1790304 | — | GWAS association (p=6.0e-15) | Major Consortium Study |
| rs17228058 | SMAD3 | GWAS association (p=8.0e-15) | Major Consortium Study |
| rs16986953 | — | GWAS association (p=9.0e-15) | Major Consortium Study |
| rs974819 | — | GWAS association (p=9.0e-15) | Major Consortium Study |
| rs72957606 | — | GWAS association (p=1.0e-14) | Major Consortium Study |
| rs73437358 | ATP2B1 | GWAS association (p=1.0e-14) | Major Consortium Study |
| rs1421085 | FTO | GWAS association (p=2.0e-14) | Major Consortium Study |
| rs72664355 | PLPP3 | GWAS association (p=2.0e-14) | Major Consortium Study |
| rs6504213 | — | GWAS association (p=4.0e-14) | Major Consortium Study |
| rs4299376 | ABCG8 | GWAS association (p=6.0e-14) | Major Consortium Study |
| rs1333042 | CDKN2B-AS1 | GWAS association (p=9.0e-14) | Major Consortium Study |
| rs7766436 | — | GWAS association (p=1.0e-13) | Major Consortium Study |
| rs116843064 | ANGPTL4 | GWAS association (p=3.0e-13) | Major Consortium Study |
| rs1712248 | — | GWAS association (p=3.0e-13) | Major Consortium Study |
| rs6227 | FURIN | GWAS association (p=3.0e-13) | Major Consortium Study |
| rs9337951 | — | GWAS association (p=4.0e-13) | Major Consortium Study |
| rs554710059 | — | GWAS association (p=5.0e-13) | Major Consortium Study |
| rs4766578 | ATXN2 | GWAS association (p=7.0e-13) | Major Consortium Study |
| rs2943653 | — | GWAS association (p=1.0e-12) | Major Consortium Study |
| rs4845621 | IL6R | GWAS association (p=1.0e-12) | Major Consortium Study |
| rs334 | HBB | GWAS association (p=2.0e-12) | Major Consortium Study |
| rs78088000 | MYO7B | GWAS association (p=5.0e-12) | Major Consortium Study |
| rs4245791 | ABCG8 | GWAS association (p=6.0e-12) | Major Consortium Study |
| rs564817874 | — | GWAS association (p=7.0e-12) | Major Consortium Study |
| rs4970966 | — | GWAS association (p=8.0e-12) | Major Consortium Study |
| rs111276643 | FAM171A1 | GWAS association (p=2.0e-11) | Major Consortium Study |
| rs787429 | — | GWAS association (p=2.0e-11) | Major Consortium Study |
| rs35911833 | HHIPL1 | GWAS association (p=2.0e-11) | Major Consortium Study |
| rs10886430 | GRK5 | GWAS association (p=3.0e-11) | Major Consortium Study |
| rs536469399 | TAFA1 | GWAS association (p=3.0e-11) | Major Consortium Study |
| rs565672113 | SLC49A4 | GWAS association (p=3.0e-11) | Major Consortium Study |
| rs7798197 | — | GWAS association (p=4.0e-11) | Major Consortium Study |
| rs190712692 | — | GWAS association (p=4.0e-11) | Major Consortium Study |
| rs8176749 | ABO | GWAS association (p=7.0e-21) | Major Consortium Study |
| rs115478735 | ABO | GWAS association (p=4.0e-85) | Major Consortium Study |
| rs12445050 | — | GWAS association (p=7.0e-18) | Major Consortium Study |
| rs17490626 | — | GWAS association (p=3.0e-26) | Major Consortium Study |
| rs1799963 | F2 | GWAS association (p=7.0e-59) | Major Consortium Study |
| rs1894692 | — | GWAS association (p=2.0e-105) | Major Consortium Study |
| rs2066865 | FGG | GWAS association (p=7.0e-59) | Major Consortium Study |
| rs4444878 | — | GWAS association (p=2.0e-64) | Major Consortium Study |
| rs115364369 | VWF | GWAS association (p=4.0e-12) | Major Consortium Study |
| rs74437754 | PROS1 | GWAS association (p=2.0e-16) | Major Consortium Study |
| rs74492489 | IWS1 | GWAS association (p=3.0e-16) | Major Consortium Study |
| rs564399474 | — | GWAS association (p=1.0e-11) | Large GWAS |
| rs182592259 | ATG2B | GWAS association (p=9.0e-09) | Large GWAS |
| rs139809494 | — | GWAS association (p=1.0e-08) | Large GWAS |
| rs2181386 | — | GWAS association (p=4.0e-08) | Large GWAS |
Associations aggregated from the GWAS Catalog and curated literature. Informational only — not medical advice.