GRK5
G protein-coupled receptor kinase 5
Pharmacogene
Summary
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. It has also been shown to play a role in regulating the motility of polymorphonuclear leukocytes (PMNs). [provided by RefSeq, Jul 2008]
Known Variants56 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs11198821 | 10:120,965,341 | A/G | upstream gene variant | — |
| rs1397615 | 10:120,966,339 | T/A | — | — |
| rs1980030 | 10:120,970,027 | G/A | upstream gene variant | — |
| rs10466210 | 10:120,970,381 | A/C | — | — |
| rs9325562 | 10:120,970,543 | G/A | upstream gene variant | — |
| rs10886430 | 10:121,010,256 | G/A | — | benign |
| rs7071131 | 10:121,026,712 | A/G | intron variant | — |
| rs11198861 | 10:121,049,819 | G/T | — | — |
| rs871199 | 10:121,068,380 | G/C | — | — |
| rs1216070478 | 10:121,086,076 | T/G | — | uncertain significance |
| rs576302427 | 10:121,086,090 | A/G | — | uncertain significance |
| rs2230345 | 10:121,086,097 | A/T | missense | — |
| rs1394632002 | 10:121,086,106 | A/G | — | uncertain significance |
| rs747058699 | 10:121,086,120 | A/T | — | uncertain significance |
| rs10787955 | 10:121,096,836 | G/A | upstream gene variant | — |
| rs2275036 | 10:121,140,321 | C/T | splice region variant | — |
| rs561959438 | 10:121,140,333 | A/T | — | uncertain significance |
| rs150876579 | 10:121,140,334 | T/G | — | uncertain significance |
| rs10886471 | 10:121,149,403 | C/T | regulatory region variant | — |
| rs969072084 | 10:121,156,273 | C/T | — | uncertain significance |
| rs10437498 | 10:121,168,259 | A/T | — | — |
| rs4752307 | 10:121,182,409 | G/A | regulatory region variant | — |
| rs11198918 | 10:121,182,580 | T/C | regulatory region variant | — |
| rs55980792 | 10:121,182,694 | C/T | — | benign |
| rs56254855 | 10:121,182,759 | C/A | — | benign |
| rs114716704 | 10:121,182,787 | C/T | — | benign |
| rs200231122 | 10:121,182,788 | G/A | — | likely benign |
| rs142641433 | 10:121,184,515 | G/C | — | uncertain significance |
| rs116686924 | 10:121,189,899 | C/G | — | likely benign |
| rs1406966316 | 10:121,189,911 | C/A | — | uncertain significance |
| rs2493522065 | 10:121,190,903 | G/A | — | uncertain significance |
| rs564130593 | 10:121,190,947 | C/T | — | uncertain significance |
| rs759135424 | 10:121,196,280 | G/A | — | uncertain significance |
| rs762125001 | 10:121,196,304 | G/C | — | uncertain significance |
| rs769347901 | 10:121,196,346 | G/A | — | uncertain significance |
| rs143794689 | 10:121,201,559 | G/A | — | uncertain significance |
| rs1011638074 | 10:121,201,570 | C/T | — | uncertain significance |
| rs769875126 | 10:121,201,573 | G/A | — | uncertain significance |
| rs116059103 | 10:121,203,081 | G/T | — | uncertain significance |
| rs557203104 | 10:121,203,154 | C/T | — | uncertain significance |
| rs143962659 | 10:121,203,194 | G/A | — | uncertain significance |
| rs748302706 | 10:121,203,197 | G/A | — | uncertain significance |
| rs141164889 | 10:121,203,237 | C/T | — | benign |
| rs77323445 | 10:121,207,642 | C/T | — | benign |
| rs2493555393 | 10:121,207,703 | C/A | — | uncertain significance |
| rs139222578 | 10:121,207,710 | T/C | — | benign |
| rs1265890823 | 10:121,207,746 | A/C | — | uncertain significance |
| rs751729008 | 10:121,207,764 | G/A | — | likely benign |
| rs1853312774 | 10:121,212,189 | G/A | — | uncertain significance |
| rs1853314982 | 10:121,212,301 | C/T | — | uncertain significance |
| rs200305868 | 10:121,212,317 | C/T | — | likely benign |
| rs760745107 | 10:121,212,689 | C/A | — | uncertain significance |
| rs761541959 | 10:121,212,706 | G/A | — | uncertain significance |
| rs766184775 | 10:121,212,784 | G/A | — | uncertain significance |
| rs147119258 | 10:121,214,520 | A/T | — | uncertain significance |
| rs138518818 | 10:121,214,535 | A/G | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.