rs74492489

This is a coding sequence variant variant in the IWS1 gene.

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GWAS Catalog Trait Associations (4)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

pulmonary embolism, Pulmonary Infarction

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele A
OR 0.58
p 1.0e-14
N 120,880
Major Consortium StudyLarge GWAS
African American or Afro-Caribbean

deep vein thrombosis

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele A
OR 0.59
p 4.0e-18
N 119,901
Major Consortium StudyLarge GWAS
African American or Afro-Caribbean

heart disease

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele A
OR 0.58
p 7.0e-15
N 120,829
Major Consortium StudyLarge GWAS
African American or Afro-Caribbean

Thromboembolism

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele A
OR 0.58
p 2.0e-26
N 118,315
Major Consortium StudyLarge GWAS
African American or Afro-Caribbean

About IWS1

Involved in regulation of mRNA export from nucleus; regulation of mRNA processing; and transcription elongation-coupled chromatin remodeling. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

View all IWS1 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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