NOS3

nitric oxide synthase 3

Summary

Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. Nitric oxide is synthesized from L-arginine by nitric oxide synthases. Variations in this gene are associated with susceptibility to coronary spasm. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Oct 2016]

Known Variants156 total

rsidPosition (GRCh37)AllelesClassClinVar
rs117714437:150,687,687C/Tregulatory region variant—
rs18007837:150,689,397A/Tintron variant—
rs18007797:150,689,943G/Aregulatory region variant—
rs20707447:150,690,079C/Tregulatory region variantbenign
rs39182267:150,690,176C/Tregulatory region variant—
rs7528897527:150,690,915C/T—likely benign
rs7575893997:150,690,926G/A—uncertain significance
rs1996423177:150,690,969C/T—likely benign
rs18023104667:150,691,012G/T—uncertain significance
rs7557108907:150,691,037C/T—uncertain significance
rs7523098887:150,692,304C/T—likely pathogenic
rs10073209957:150,692,357G/C—uncertain significance
rs7542676617:150,692,359T/C—uncertain significance
rs1812420837:150,692,411G/A—likely benign
rs18007817:150,692,444G/A—benign
rs119740987:150,693,430C/G—benign
rs7461795197:150,693,485G/T—likely benign
rs9710952967:150,693,492G/A—uncertain significance
rs18024245367:150,693,505C/T—uncertain significance
rs14047687057:150,693,513C/T—uncertain significance
rs39181667:150,693,556G/A—benign
rs24862052427:150,693,589T/C—uncertain significance
rs7671149867:150,693,592T/G—uncertain significance
rs1492246297:150,693,598A/T—uncertain significance
rs1433241647:150,693,603C/T—uncertain significance
rs1483599177:150,693,604G/A—benign
rs2007747207:150,693,896C/G—likely benign
rs7658541607:150,693,936G/A—likely pathogenic
rs1457118027:150,693,947C/A—uncertain significance
rs7466095367:150,693,951G/A—likely benign
rs7630961457:150,695,470C/A—uncertain significance
rs12177722987:150,695,491A/G—uncertain significance
rs7532795697:150,695,531C/G—uncertain significance
rs7591503257:150,695,648G/A—likely benign
rs17947842257:150,695,656G/T—uncertain significance
rs12249186077:150,695,706G/T—uncertain significance
rs15497587:150,695,726T/C—benign
rs5521654507:150,695,728G/A—uncertain significance
rs5277537757:150,695,729C/G—likely benign
rs12386258227:150,695,742G/T—uncertain significance
rs352812207:150,695,753C/T—likely benign
rs7714856247:150,695,777C/T—likely benign
rs2013825407:150,695,778G/A—likely benign
rs10073117:150,696,008G/A—benign
rs92828037:150,696,066C/T—benign
rs1391841267:150,696,067G/A—uncertain significance
rs3748343157:150,696,071G/A—uncertain significance
rs1495398137:150,696,076G/A—benign
rs92828047:150,696,078C/T—benign
rs17999837:150,696,111T/Gmissense variantpathogenic
rs12217249807:150,696,136C/G—uncertain significance
rs3694890947:150,696,139G/A—uncertain significance
rs1492550327:150,696,271C/T—benign
rs7567378387:150,696,284G/A—likely benign
rs1842220227:150,696,303C/T—likely benign
rs17950217467:150,696,373C/T—uncertain significance
rs1444396827:150,696,461C/T—likely benign
rs15418617:150,697,333C/Aintron variantbenign
rs734725367:150,697,387G/A—benign
rs17950657247:150,697,601A/C—uncertain significance
rs7582409367:150,697,664G/A—uncertain significance
rs10125192367:150,698,336C/T—likely benign
rs9533259857:150,698,337G/A—uncertain significance
rs1509354887:150,698,349G/A—likely benign
rs5346640577:150,698,351C/T—likely benign
rs1410899407:150,698,352G/A—benign
rs5781017037:150,698,356C/T—uncertain significance
rs7654524177:150,698,498G/A—likely benign
rs7642712777:150,698,506G/A—uncertain significance
rs17950988417:150,698,666C/T—uncertain significance
rs1382691107:150,698,667C/G—likely benign
rs18007807:150,698,879A/Gintron variantbenign
rs7456934477:150,698,905G/A—likely benign
rs7746093597:150,698,913G/A—uncertain significance
rs7655728037:150,698,965C/T—uncertain significance
rs3707551057:150,699,008C/T—likely benign
rs18007827:150,699,250G/T—benign
rs1474109687:150,699,296T/C—likely benign
rs13812353677:150,699,347G/A—likely benign
rs15849057307:150,699,353C/T—likely benign
rs755289017:150,699,611C/G—benign
rs28537927:150,699,877G/Aintron variant—
rs5403039447:150,700,240G/A—uncertain significance
rs794674117:150,700,291A/G—benign
rs731676527:150,700,637A/G—benign
rs39182277:150,700,946C/Aregulatory region variantbenign
rs39181817:150,701,783G/Aintron variant—
rs39181887:150,702,781C/T——
rs28537957:150,703,242A/Gintron variant—
rs7751966867:150,703,570C/T—uncertain significance
rs28537967:150,703,915G/Tintron variantbenign
rs7610887897:150,704,198T/C—uncertain significance
rs21171283377:150,704,203G/A—uncertain significance
rs77921337:150,704,246G/A—benign
rs25665147:150,704,250C/G—benign
rs7751136827:150,704,373A/G—likely benign
rs37303057:150,704,400A/C—benign
rs39181967:150,705,842A/G—benign
rs1489093797:150,706,014G/A—likely benign
rs24862405147:150,706,025G/C—uncertain significance

Showing 100 of 156 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.

NOS3 — nitric oxide synthase 3