ZC3HC1
zinc finger C3HC-type containing 1
Summary
This gene encodes an F-box-containing protein that is a component of an SCF-type E3 ubiquitin ligase complex that regulates the onset of cell division. The G2/M transition in the cell cycle requires the interaction of the proteins cyclin B1 and cyclin-dependent kinase 1. The activated ubiquitin ligase complex targets the protein cyclin B1 for degradation, preventing this transition to mitosis. [provided by RefSeq, Aug 2013]
Known Variants40 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs2242487 | 7:129,657,882 | A/G | downstream gene variant | — |
| rs185837522 | 7:129,658,532 | C/T | — | uncertain significance |
| rs150122551 | 7:129,662,169 | G/A | — | uncertain significance |
| rs1422215591 | 7:129,662,196 | T/A | — | uncertain significance |
| rs149257210 | 7:129,662,245 | C/T | — | likely benign |
| rs1244160102 | 7:129,663,353 | A/C | — | uncertain significance |
| rs202243776 | 7:129,663,373 | C/T | — | uncertain significance |
| rs1563073957 | 7:129,663,374 | G/A | — | uncertain significance |
| rs758653297 | 7:129,663,377 | C/G | — | uncertain significance |
| rs879868826 | 7:129,663,379 | C/T | — | uncertain significance |
| rs944650210 | 7:129,663,391 | C/T | — | uncertain significance |
| rs11556924 | 7:129,663,496 | C/A | missense variant | — |
| rs757420514 | 7:129,663,516 | G/C | — | uncertain significance |
| rs756680606 | 7:129,663,526 | C/T | — | uncertain significance |
| rs567287067 | 7:129,663,527 | G/A | — | uncertain significance |
| rs200274826 | 7:129,664,183 | G/A | — | uncertain significance |
| rs375012856 | 7:129,664,204 | C/G | — | uncertain significance |
| rs200223575 | 7:129,664,252 | T/C | — | uncertain significance |
| rs1464890 | 7:129,664,312 | T/G | missense variant | — |
| rs180980614 | 7:129,666,091 | C/A | — | uncertain significance |
| rs145258539 | 7:129,668,856 | C/T | — | uncertain significance |
| rs4507692 | 7:129,670,412 | T/G | — | — |
| rs1409339819 | 7:129,679,306 | G/T | — | uncertain significance |
| rs1419847786 | 7:129,679,322 | G/A | — | uncertain significance |
| rs2535761786 | 7:129,679,348 | G/T | — | uncertain significance |
| rs199892050 | 7:129,680,795 | G/C | — | uncertain significance |
| rs750984317 | 7:129,680,860 | T/C | — | uncertain significance |
| rs780078834 | 7:129,680,899 | C/T | — | uncertain significance |
| rs200857556 | 7:129,680,902 | G/A | — | uncertain significance |
| rs535754752 | 7:129,681,034 | T/A | — | — |
| rs9641864 | 7:129,686,608 | T/A | intron variant | — |
| rs775738259 | 7:129,688,884 | C/T | — | uncertain significance |
| rs1485159808 | 7:129,688,902 | C/T | — | uncertain significance |
| rs371593881 | 7:129,688,951 | A/T | — | uncertain significance |
| rs763969059 | 7:129,691,092 | C/A | — | uncertain significance |
| rs568344139 | 7:129,691,113 | T/C | — | likely benign |
| rs140747380 | 7:129,691,122 | G/A | — | uncertain significance |
| rs145290627 | 7:129,691,124 | G/T | — | uncertain significance |
| rs769302080 | 7:129,691,133 | G/A | — | uncertain significance |
| rs779499534 | 7:129,691,134 | G/A | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.