rs2242487
This is a downstream gene variant variant in the ZC3HC1 gene.
▶Research that mentions this SNP (1)
▶The genetic polymorphisms of ZC3HC1 and SMARCA4 are associated with hypertension riskAssociationN=833Huijun Ma et al.(2019)· Molecular Genetics & Genomic Medicine
Case-control study of 350 hypertension patients and 483 controls in Chinese Han population examined 8 SNPs in ZC3HC1 and SMARCA4 genes. rs1464890 and rs4507692 in ZC3HC1 showed protective effects (OR=0.68-0.69, 0.65-0.66 in codominant/dominant models), as did rs11879293 and rs1122608 in SMARCA4 (OR=0.70, 0.61). The 'ATT' ZC3HC1 haplotype was associated with 0.75-fold decreased hypertension risk.
About ZC3HC1
This gene encodes an F-box-containing protein that is a component of an SCF-type E3 ubiquitin ligase complex that regulates the onset of cell division. The G2/M transition in the cell cycle requires the interaction of the proteins cyclin B1 and cyclin-dependent kinase 1. The activated ubiquitin ligase complex targets the protein cyclin B1 for degradation, preventing this transition to mitosis. [provided by RefSeq, Aug 2013]
View all ZC3HC1 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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