rs145258539

This variant is located in the ZC3HC1 gene.

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ClinVar annotation

Uncertain Significance★☆☆☆

1 submitter

not specified

About ZC3HC1

This gene encodes an F-box-containing protein that is a component of an SCF-type E3 ubiquitin ligase complex that regulates the onset of cell division. The G2/M transition in the cell cycle requires the interaction of the proteins cyclin B1 and cyclin-dependent kinase 1. The activated ubiquitin ligase complex targets the protein cyclin B1 for degradation, preventing this transition to mitosis. [provided by RefSeq, Aug 2013]

View all ZC3HC1 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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